The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation

The WRN helicase/exonuclease protein is required for proper replication fork recovery and maintenance of genome stability. However, whether the different catalytic activities of WRN cooperate to recover replication forks in vivo is unknown. Here, we show that, in response to replication perturbation...

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Detalles Bibliográficos
Autores principales: Iannascoli, Chiara, Palermo, Valentina, Murfuni, Ivana, Franchitto, Annapaola, Pichierri, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787784/
https://www.ncbi.nlm.nih.gov/pubmed/26275776
http://dx.doi.org/10.1093/nar/gkv836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787784/
https://www.ncbi.nlm.nih.gov/pubmed/26275776
http://dx.doi.org/10.1093/nar/gkv836

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