Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses

RNA viruses encode an RNA-dependent RNA polymerase (RdRp) that catalyzes the synthesis of their RNA(s). In the case of positive-stranded RNA viruses belonging to the order Nidovirales, the RdRp resides in a replicase subunit that is unusually large. Bioinformatics analysis of this non-structural pro...

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Detalles Bibliográficos
Autores principales: Lehmann, Kathleen C., Gulyaeva, Anastasia, Zevenhoven-Dobbe, Jessika C., Janssen, George M. C., Ruben, Mark, Overkleeft, Hermen S., van Veelen, Peter A., Samborskiy, Dmitry V., Kravchenko, Alexander A., Leontovich, Andrey M., Sidorov, Igor A., Snijder, Eric J., Posthuma, Clara C., Gorbalenya, Alexander E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787807/
https://www.ncbi.nlm.nih.gov/pubmed/26304538
http://dx.doi.org/10.1093/nar/gkv838

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