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DNA polymerases κ and ζ cooperatively perform mutagenic translesion synthesis of the C8–2′-deoxyguanosine adduct of the dietary mutagen IQ in human cells

The roles of translesion synthesis (TLS) DNA polymerases in bypassing the C8–2′-deoxyguanosine adduct (dG-C8-IQ) formed by 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), a highly mutagenic and carcinogenic heterocyclic amine found in cooked meats, were investigated. Three plasmid vectors containing t...

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Detalles Bibliográficos
Autores principales:	Bose, Arindam, Pande, Paritosh, Jasti, Vijay P., Millsap, Amy D., Hawkins, Edward K., Rizzo, Carmelo J., Basu, Ashis K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787813/ https://www.ncbi.nlm.nih.gov/pubmed/26220181 http://dx.doi.org/10.1093/nar/gkv750

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