Meta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene

Nonsyndromic orofacial clefts are common birth defects with multifactorial etiology. The most common type is cleft lip, which occurs with or without cleft palate (nsCLP and nsCLO, respectively). Although genetic components play an important role in nsCLP, the genetic factors that predispose to palat...

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Detalles Bibliográficos
Autores principales: Ludwig, Kerstin U., Ahmed, Syeda Tasnim, Böhmer, Anne C., Sangani, Nasim Bahram, Varghese, Sheryil, Klamt, Johanna, Schuenke, Hannah, Gültepe, Pinar, Hofmann, Andrea, Rubini, Michele, Aldhorae, Khalid Ahmed, Steegers-Theunissen, Regine P., Rojas-Martinez, Augusto, Reiter, Rudolf, Borck, Guntram, Knapp, Michael, Nakatomi, Mitsushiro, Graf, Daniel, Mangold, Elisabeth, Peters, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788144/
https://www.ncbi.nlm.nih.gov/pubmed/26968009
http://dx.doi.org/10.1371/journal.pgen.1005914

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