Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces

In this paper we introduce a fully flexible coarse-grained model of immunoglobulin G (IgG) antibodies parametrized directly on cryo-EM data and simulate the binding dynamics of many IgGs to antigens adsorbed on a surface at increasing densities. Moreover, we work out a theoretical model that allows...

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Detalles Bibliográficos
Autores principales: De Michele, Cristiano, De Los Rios, Paolo, Foffi, Giuseppe, Piazza, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788199/
https://www.ncbi.nlm.nih.gov/pubmed/26967624
http://dx.doi.org/10.1371/journal.pcbi.1004752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788199/
https://www.ncbi.nlm.nih.gov/pubmed/26967624
http://dx.doi.org/10.1371/journal.pcbi.1004752

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