Short Hairpin RNA Silencing of PHD-2 Improves Neovascularization and Functional Outcomes in Diabetic Wounds and Ischemic Limbs

The transcription factor hypoxia-inducible factor 1-alpha (HIF-1α) is responsible for the downstream expression of over 60 genes that regulate cell survival and metabolism in hypoxic conditions as well as those that enhance angiogenesis to alleviate hypoxia. However, under normoxic conditions, HIF-1...

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Detalles Bibliográficos
Autores principales: Paik, Kevin J., Maan, Zeshaan N., Zielins, Elizabeth R., Duscher, Dominik, Whittam, Alexander J., Morrison, Shane D., Brett, Elizabeth A., Ransom, Ryan C., Hu, Michael S., Wu, Joseph C., Gurtner, Geoffrey C., Longaker, Michael T., Wan, Derrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788284/
https://www.ncbi.nlm.nih.gov/pubmed/26967994
http://dx.doi.org/10.1371/journal.pone.0150927

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