Simvastatin increases the antineoplastic actions of paclitaxel carried in lipid nanoemulsions in melanoma-bearing mice

PURPOSE: Lipid nanoemulsions (LDEs) that bind to low-density lipoprotein (LDL) receptors used as carriers of paclitaxel (PTX) can decrease toxicity and increase PTX antitumoral action. The administration of simvastatin (Simva), which lowers LDL-cholesterol, was tested as an adjuvant to commercial PT...

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Detalles Bibliográficos
Autores principales: Kretzer, Iara F, Maria, Durvanei A, Guido, Maria C, Contente, Thaís C, Maranhão, Raul C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788363/
https://www.ncbi.nlm.nih.gov/pubmed/27022257
http://dx.doi.org/10.2147/IJN.S88546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788363/
https://www.ncbi.nlm.nih.gov/pubmed/27022257
http://dx.doi.org/10.2147/IJN.S88546

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