Distinguishing Antimicrobial Models with Different Resistance Mechanisms via Population Pharmacodynamic Modeling

Semi-mechanistic pharmacokinetic-pharmacodynamic (PK-PD) modeling is increasingly used for antimicrobial drug development and optimization of dosage regimens, but systematic simulation-estimation studies to distinguish between competing PD models are lacking. This study compared the ability of stati...

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Detalles Bibliográficos
Autores principales: Jacobs, Matthieu, Grégoire, Nicolas, Couet, William, Bulitta, Jurgen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788427/
https://www.ncbi.nlm.nih.gov/pubmed/26967893
http://dx.doi.org/10.1371/journal.pcbi.1004782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788427/
https://www.ncbi.nlm.nih.gov/pubmed/26967893
http://dx.doi.org/10.1371/journal.pcbi.1004782

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