Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response

Peptidyl arginine deiminase 4 (PAD4) is a nuclear enzyme that converts arginine residues to citrulline. Although increasingly implicated in inflammatory disease and cancer, the mechanism of action of PAD4 and its functionally relevant pathways remains unclear. E2F transcription factors are a family...

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Detalles Bibliográficos
Autores principales: Ghari, Fatemeh, Quirke, Anne-Marie, Munro, Shonagh, Kawalkowska, Joanna, Picaud, Sarah, McGouran, Joanna, Subramanian, Venkataraman, Muth, Aaron, Williams, Richard, Kessler, Benedikt, Thompson, Paul R., Fillipakopoulos, Panagis, Knapp, Stefan, Venables, Patrick J., La Thangue, Nicholas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788482/
https://www.ncbi.nlm.nih.gov/pubmed/26989780
http://dx.doi.org/10.1126/sciadv.1501257

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