(1)H, (15)N, (13)C resonance assignment of human GAP-43

GAP-43 is a 25 kDa neuronal intrinsically disordered protein, highly abundant in the neuronal growth cone during development and regeneration. The exact molecular function(s) of GAP-43 remains unclear but it appears to be involved in growth cone guidance and actin cytoskeleton organization. Therefor...

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Autores principales: Flamm, Andrea Gabriele, Żerko, Szymon, Zawadzka-Kazimierczuk, Anna, Koźmiński, Wiktor, Konrat, Robert, Coudevylle, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788685/
https://www.ncbi.nlm.nih.gov/pubmed/26748655
http://dx.doi.org/10.1007/s12104-015-9660-9
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author Flamm, Andrea Gabriele
Żerko, Szymon
Zawadzka-Kazimierczuk, Anna
Koźmiński, Wiktor
Konrat, Robert
Coudevylle, Nicolas
author_facet Flamm, Andrea Gabriele
Żerko, Szymon
Zawadzka-Kazimierczuk, Anna
Koźmiński, Wiktor
Konrat, Robert
Coudevylle, Nicolas
author_sort Flamm, Andrea Gabriele
collection PubMed
description GAP-43 is a 25 kDa neuronal intrinsically disordered protein, highly abundant in the neuronal growth cone during development and regeneration. The exact molecular function(s) of GAP-43 remains unclear but it appears to be involved in growth cone guidance and actin cytoskeleton organization. Therefore, GAP-43 seems to play an important role in neurotransmitter vesicle fusion and recycling, long-term potentiation, spatial memory formation and learning. Here we report the nearly complete assignment of recombinant human GAP-43. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12104-015-9660-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-47886852016-04-09 (1)H, (15)N, (13)C resonance assignment of human GAP-43 Flamm, Andrea Gabriele Żerko, Szymon Zawadzka-Kazimierczuk, Anna Koźmiński, Wiktor Konrat, Robert Coudevylle, Nicolas Biomol NMR Assign Article GAP-43 is a 25 kDa neuronal intrinsically disordered protein, highly abundant in the neuronal growth cone during development and regeneration. The exact molecular function(s) of GAP-43 remains unclear but it appears to be involved in growth cone guidance and actin cytoskeleton organization. Therefore, GAP-43 seems to play an important role in neurotransmitter vesicle fusion and recycling, long-term potentiation, spatial memory formation and learning. Here we report the nearly complete assignment of recombinant human GAP-43. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12104-015-9660-9) contains supplementary material, which is available to authorized users. Springer Netherlands 2016-01-09 2016 /pmc/articles/PMC4788685/ /pubmed/26748655 http://dx.doi.org/10.1007/s12104-015-9660-9 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Flamm, Andrea Gabriele
Żerko, Szymon
Zawadzka-Kazimierczuk, Anna
Koźmiński, Wiktor
Konrat, Robert
Coudevylle, Nicolas
(1)H, (15)N, (13)C resonance assignment of human GAP-43
title (1)H, (15)N, (13)C resonance assignment of human GAP-43
title_full (1)H, (15)N, (13)C resonance assignment of human GAP-43
title_fullStr (1)H, (15)N, (13)C resonance assignment of human GAP-43
title_full_unstemmed (1)H, (15)N, (13)C resonance assignment of human GAP-43
title_short (1)H, (15)N, (13)C resonance assignment of human GAP-43
title_sort (1)h, (15)n, (13)c resonance assignment of human gap-43
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788685/
https://www.ncbi.nlm.nih.gov/pubmed/26748655
http://dx.doi.org/10.1007/s12104-015-9660-9
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