Intracellular pharmacokinetic study of zidovudine and its phosphorylated metabolites

Zidovudine (AZT), the first drug approved by the US Food and Drug Administration for the treatment of human immunodeficiency virus (HIV) infection, is metabolized in the host cells to 5′-AZT triphosphate (AZT-TP) which inhibits HIV reverse transcriptase. As the pharmacokinetics of AZT and its phosph...

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Detalles Bibliográficos
Autores principales: Mu, Lingli, Zhou, Rui, Tang, Fang, Liu, Xingling, Li, Sanwang, Xie, Feifan, Xie, Xiang, Peng, Jie, Yu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788712/
https://www.ncbi.nlm.nih.gov/pubmed/27006900
http://dx.doi.org/10.1016/j.apsb.2015.10.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788712/
https://www.ncbi.nlm.nih.gov/pubmed/27006900
http://dx.doi.org/10.1016/j.apsb.2015.10.002

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