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Injected nanocrystals for targeted drug delivery

Nanocrystals are pure drug crystals with sizes in the nanometer range. Due to the advantages of high drug loading, platform stability, and ease of scaling-up, nanocrystals have been widely used to deliver poorly water-soluble drugs. Nanocrystals in the blood stream can be recognized and sequestered...

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Detalles Bibliográficos
Autores principales: Lu, Yi, Li, Ye, Wu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788714/
https://www.ncbi.nlm.nih.gov/pubmed/27006893
http://dx.doi.org/10.1016/j.apsb.2015.11.005
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author Lu, Yi
Li, Ye
Wu, Wei
author_facet Lu, Yi
Li, Ye
Wu, Wei
author_sort Lu, Yi
collection PubMed
description Nanocrystals are pure drug crystals with sizes in the nanometer range. Due to the advantages of high drug loading, platform stability, and ease of scaling-up, nanocrystals have been widely used to deliver poorly water-soluble drugs. Nanocrystals in the blood stream can be recognized and sequestered as exogenous materials by mononuclear phagocytic system (MPS) cells, leading to passive accumulation in MPS-rich organs, such as liver, spleen and lung. Particle size, morphology and surface modification affect the biodistribution of nanocrystals. Ligand conjugation and stimuli-responsive polymers can also be used to target nanocrystals to specific pathogenic sites. In this review, the progress on injected nanocrystals for targeted drug delivery is discussed following a brief introduction to nanocrystal preparation methods, i.e., top-down and bottom-up technologies.
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spelling pubmed-47887142016-03-22 Injected nanocrystals for targeted drug delivery Lu, Yi Li, Ye Wu, Wei Acta Pharm Sin B Review Nanocrystals are pure drug crystals with sizes in the nanometer range. Due to the advantages of high drug loading, platform stability, and ease of scaling-up, nanocrystals have been widely used to deliver poorly water-soluble drugs. Nanocrystals in the blood stream can be recognized and sequestered as exogenous materials by mononuclear phagocytic system (MPS) cells, leading to passive accumulation in MPS-rich organs, such as liver, spleen and lung. Particle size, morphology and surface modification affect the biodistribution of nanocrystals. Ligand conjugation and stimuli-responsive polymers can also be used to target nanocrystals to specific pathogenic sites. In this review, the progress on injected nanocrystals for targeted drug delivery is discussed following a brief introduction to nanocrystal preparation methods, i.e., top-down and bottom-up technologies. Elsevier 2016-03 2016-01-11 /pmc/articles/PMC4788714/ /pubmed/27006893 http://dx.doi.org/10.1016/j.apsb.2015.11.005 Text en © 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Lu, Yi
Li, Ye
Wu, Wei
Injected nanocrystals for targeted drug delivery
title Injected nanocrystals for targeted drug delivery
title_full Injected nanocrystals for targeted drug delivery
title_fullStr Injected nanocrystals for targeted drug delivery
title_full_unstemmed Injected nanocrystals for targeted drug delivery
title_short Injected nanocrystals for targeted drug delivery
title_sort injected nanocrystals for targeted drug delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788714/
https://www.ncbi.nlm.nih.gov/pubmed/27006893
http://dx.doi.org/10.1016/j.apsb.2015.11.005
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