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BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo

Hematopoietic stem cells (HSC), the self-renewing cells of the adult blood differentiation hierarchy, are generated during embryonic stages. The first HSCs are produced in the aorta-gonad-mesonephros (AGM) region of the embryo through endothelial to a hematopoietic transition. BMP4 and Hedgehog affe...

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Detalles Bibliográficos
Autores principales:	Crisan, Mihaela, Solaimani Kartalaei, Parham, Neagu, Alex, Karkanpouna, Sofia, Yamada-Inagawa, Tomoko, Purini, Caterina, Vink, Chris S., van der Linden, Reinier, van Ijcken, Wilfred, Chuva de Sousa Lopes, Susana M., Monteiro, Rui, Mummery, Christine, Dzierzak, Elaine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788785/ https://www.ncbi.nlm.nih.gov/pubmed/26923823 http://dx.doi.org/10.1016/j.stemcr.2016.01.016

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