Prevalence of salivary epstein-barr virus in potentially malignant oral disorders and oral squamous cell carcinoma

BACKGROUND: To analyze the presence of salivary Epstein-Barr virus (EBV) DNA in oral squamous cell carcinoma and potentially malignant oral disorders. MATERIAL AND METHODS: Three groups were studied: Group 1 (12 oral squamous cell carcinomas (OSCC)), Group 2 (12 potentially malignant oral disorders...

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Detalles Bibliográficos
Autores principales: Bagan, Leticia, Ocete-Monchon, María-Dolores, Leopoldo-Rodado, Manuel, Murillo-Cortes, Judith, Díaz-Fernández, Jose-M., Medina-Gonzalez, Rafael, Gimeno-Cardona, Concepción, Bagan, Jose-V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788793/
https://www.ncbi.nlm.nih.gov/pubmed/26827058
http://dx.doi.org/10.4317/medoral.20785
Descripción
Sumario:BACKGROUND: To analyze the presence of salivary Epstein-Barr virus (EBV) DNA in oral squamous cell carcinoma and potentially malignant oral disorders. MATERIAL AND METHODS: Three groups were studied: Group 1 (12 oral squamous cell carcinomas (OSCC)), Group 2 (12 potentially malignant oral disorders (PMD)) and Group 3 (47 healthy controls). EBV DNA salivary analysis was performed by PCR. RESULTS: The highest percentage of positive salivary EBV DNA corresponded to the OSCC group (58.3%), followed by the PMD group (41.7%) and the controls (40.4%). The differences between groups were not statistically significant, however (p>0.05). CONCLUSIONS: Salivary EBV DNA was more prevalent in OSCC than in PMD or the controls. Key words:EBV DNA, saliva, oral squamous cell carcinoma, oral leukoplakia.

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