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Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?

It is estimated that over 190 million bisphosphonates have been prescribed worldwide. But this drug can produce adverse effects, of which osteonecrosis of the jaw and severe hypocalcemia are the most serious. It is evident that bisphosphonate administration affects multiple and diverse biochemical m...

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Autores principales: Leizaola-Cardesa, Ignacio-Osoitz, Aguilar-Salvatierra, Antonio, Gonzalez-Jaranay, Maximino, Moreu, Gerardo, Sala-Romero, María-José, Gómez-Moreno, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788805/
https://www.ncbi.nlm.nih.gov/pubmed/26827062
http://dx.doi.org/10.4317/medoral.20927
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author Leizaola-Cardesa, Ignacio-Osoitz
Aguilar-Salvatierra, Antonio
Gonzalez-Jaranay, Maximino
Moreu, Gerardo
Sala-Romero, María-José
Gómez-Moreno, Gerardo
author_facet Leizaola-Cardesa, Ignacio-Osoitz
Aguilar-Salvatierra, Antonio
Gonzalez-Jaranay, Maximino
Moreu, Gerardo
Sala-Romero, María-José
Gómez-Moreno, Gerardo
author_sort Leizaola-Cardesa, Ignacio-Osoitz
collection PubMed
description It is estimated that over 190 million bisphosphonates have been prescribed worldwide. But this drug can produce adverse effects, of which osteonecrosis of the jaw and severe hypocalcemia are the most serious. It is evident that bisphosphonate administration affects multiple and diverse biochemical mediators related to bone metabolism. This review of literature investigates four basic parameters in patients treated with bisphosphonates - parathyroid hormone (PTH), bisphosphonates, vitamin D, calcium, and jaw osteonecrosis - which are fundamental for assessing bone metabolism and so the efficacy and correct use of the drug. The imbalances generated by vitamin D and calcium deficiencies, together with their multiple systemic repercussions, have been widely researched but the outcomes of these imbalances in relation to bisphosphonate administration are not well known, and some research has indicated that they may be associated with osteonecrosis of the jaw (ONJ). The present review set out to explain the functioning of bone metabolism, the importance of different chemical mediators, the imbalances produced by incorrect use of this drug, in order to forewarn against the possible relation of these parameters with ONJ, whose physiopathology remains unknown. Medical and dental clinics should keep detailed anamneses of the use of vitamin D and calcium supplements, as it is of vital importance to maintain their correct levels in blood, given that these are related to ONJ as well as other adverse effects; this procedure is also necessary in order to ensure the correct use of the drug. Key words:Bisphosphonate-related osteonecrosis of the jaw, vitamin D, parathyroid hor
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spelling pubmed-47888052016-03-15 Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link? Leizaola-Cardesa, Ignacio-Osoitz Aguilar-Salvatierra, Antonio Gonzalez-Jaranay, Maximino Moreu, Gerardo Sala-Romero, María-José Gómez-Moreno, Gerardo Med Oral Patol Oral Cir Bucal Review It is estimated that over 190 million bisphosphonates have been prescribed worldwide. But this drug can produce adverse effects, of which osteonecrosis of the jaw and severe hypocalcemia are the most serious. It is evident that bisphosphonate administration affects multiple and diverse biochemical mediators related to bone metabolism. This review of literature investigates four basic parameters in patients treated with bisphosphonates - parathyroid hormone (PTH), bisphosphonates, vitamin D, calcium, and jaw osteonecrosis - which are fundamental for assessing bone metabolism and so the efficacy and correct use of the drug. The imbalances generated by vitamin D and calcium deficiencies, together with their multiple systemic repercussions, have been widely researched but the outcomes of these imbalances in relation to bisphosphonate administration are not well known, and some research has indicated that they may be associated with osteonecrosis of the jaw (ONJ). The present review set out to explain the functioning of bone metabolism, the importance of different chemical mediators, the imbalances produced by incorrect use of this drug, in order to forewarn against the possible relation of these parameters with ONJ, whose physiopathology remains unknown. Medical and dental clinics should keep detailed anamneses of the use of vitamin D and calcium supplements, as it is of vital importance to maintain their correct levels in blood, given that these are related to ONJ as well as other adverse effects; this procedure is also necessary in order to ensure the correct use of the drug. Key words:Bisphosphonate-related osteonecrosis of the jaw, vitamin D, parathyroid hor Medicina Oral S.L. 2016-03 2016-01-31 /pmc/articles/PMC4788805/ /pubmed/26827062 http://dx.doi.org/10.4317/medoral.20927 Text en Copyright: © 2016 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Leizaola-Cardesa, Ignacio-Osoitz
Aguilar-Salvatierra, Antonio
Gonzalez-Jaranay, Maximino
Moreu, Gerardo
Sala-Romero, María-José
Gómez-Moreno, Gerardo
Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?
title Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?
title_full Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?
title_fullStr Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?
title_full_unstemmed Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?
title_short Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?
title_sort bisphosphonates, vitamin d, parathyroid hormone, and osteonecrosis of the jaw. could there be a missing link?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788805/
https://www.ncbi.nlm.nih.gov/pubmed/26827062
http://dx.doi.org/10.4317/medoral.20927
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