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Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system

BACKGROUND: Plasma coagulation Factor XIIa (Hageman factor; encoded by F12) and kallikrein (KAL or Fletcher factor; encoded by KLKB1) are proteases of the kallikerin-kinin system involved in converting the inactive circulating prorenin to renin. Renin is a key enzyme in the formation of angiotensin...

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Detalles Bibliográficos
Autores principales:	Biswas, Nilima, Maihofer, Adam X., Mir, Saiful Anam, Rao, Fangwen, Zhang, Kuixing, Khandrika, Srikrishna, Mahata, Manjula, Friese, Ryan S., Hightower, C. Makena, Mahata, Sushil K., Baker, Dewleen G., Nievergelt, Caroline M., Vaingankar, Sucheta M., O’Connor, Daniel T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788869/ https://www.ncbi.nlm.nih.gov/pubmed/26969407 http://dx.doi.org/10.1186/s12881-016-0283-5

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