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Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing’s sarcoma through the PI3K/Akt pathway

BACKGROUND: Ewing’s sarcoma is an aggressive bone and soft tissue tumor with a high incidence in children and adolescents. Due to its high malignancy and poor prognosis, identification of novel biomarkers for intervention therapies is necessary to improve outcome. The EWS/FLI1 fusion gene is a chara...

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Detalles Bibliográficos
Autores principales:	Ren, Chongmin, Ren, Tingting, Yang, Kang, Wang, Shidong, Bao, Xing, Zhang, Fan, Guo, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788902/ https://www.ncbi.nlm.nih.gov/pubmed/26969300 http://dx.doi.org/10.1186/s13046-016-0321-3

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