Cargando…

A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population

BACKGROUND: To investigate whether genetic variants of the HBV receptor gene NTCP are associated with HBV infection in the Han Chinese population. METHODS: We sequenced the entire 23 kb NTCP gene from 111 HBeAg-positive HBsAg carriers (PSE group), 110 HBeAg-negative HBsAg carriers (PS group), and 11...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Jingmin, Yang, Yuan, Xia, Mingying, Wang, Lianghui, Zhou, Weiping, Yang, Yajun, Jiang, Yueming, Wang, Hongyang, Qian, Ji, Jin, Li, Wang, Xiaofeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788942/ https://www.ncbi.nlm.nih.gov/pubmed/26968990 http://dx.doi.org/10.1186/s12885-016-2257-6

Ejemplares similares

Genetic variations of NTCP are associated with susceptibility to HBV infection and related hepatocellular carcinoma
por: Wang, Peng, et al.
Publicado: (2017)

Diverse Effects of the NTCP p.Ser267Phe Variant on Disease Progression During Chronic HBV Infection and on HBV preS1 Variability
por: Yang, Fangji, et al.
Publicado: (2019)

Spinoculation Enhances HBV Infection in NTCP-Reconstituted Hepatocytes
por: Yan, Ran, et al.
Publicado: (2015)

Key Factors for “Fishing” NTCP as a Functional Receptor for HBV and HDV
por: Yan, Huan, et al.
Publicado: (2023)

Structural insights into the HBV receptor and bile acid transporter NTCP
por: Park, Jae-Hyun, et al.
Publicado: (2022)

Innovative HBV Animal Models Based on the Entry Receptor NTCP
por: Wettengel, Jochen M., et al.
Publicado: (2020)

Elevated NTCP expression by an iPSC-derived human hepatocyte maintenance medium enhances HBV infection in NTCP-reconstituted HepG2 cells
por: Li, Xinlei, et al.
Publicado: (2021)

The NTCP p.Ser267Phe Variant Is Associated With a Faster Anti-HBV Effect on First-Line Nucleos(t)ide Analog Treatment
por: Wu, Lina, et al.
Publicado: (2021)

Regulation of the HBV Entry Receptor NTCP and its Potential in Hepatitis B Treatment
por: Li, Yan, et al.
Publicado: (2022)

IFITM3 Interacts with the HBV/HDV Receptor NTCP and Modulates Virus Entry and Infection
por: Palatini, Massimo, et al.
Publicado: (2022)

Productive HBV infection of well-differentiated, hNTCP-expressing human hepatoma-derived (Huh7) cells
por: Zhou, Ming, et al.
Publicado: (2017)

Effect of S267F variant of NTCP on the patients with chronic hepatitis B
por: Lee, Hye Won, et al.
Publicado: (2017)

Down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes prevents hepatitis B virus infection
por: Yan, Ying, et al.
Publicado: (2019)

Tyrosine 146 of the Human Na(+)/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into Hepatocytes
por: Zakrzewicz, Dariusz, et al.
Publicado: (2022)

NTCP Change in Rats of Hilar Cholangiocarcinoma and Therapeutic Significance
por: Zhang, Meng-yu, et al.
Publicado: (2022)

NTCP Deficiency Affects the Levels of Circulating Bile Acids and Induces Osteoporosis
por: Yang, Fangji, et al.
Publicado: (2022)

A genetic variant in the CD40 gene is related to HBV infection in the Chinese Han population
por: Wu, Wennan, et al.
Publicado: (2023)

Genetically edited hepatic cells expressing the NTCP-S267F variant are resistant to hepatitis B virus infection
por: Uchida, Takuro, et al.
Publicado: (2021)

Multitasking Na(+)/Taurocholate Cotransporting Polypeptide (NTCP) as a Drug Target for HBV Infection: From Protein Engineering to Drug Discovery
por: Zakrzewicz, Dariusz, et al.
Publicado: (2022)

Unlocking the secrets to human NTCP structure
por: Qi, Xiangbing, et al.
Publicado: (2022)

NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells
por: Jiao, Qian, et al.
Publicado: (2021)

The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro
por: Gad, Sameh A., et al.
Publicado: (2022)

Potentially Functional Variants of PLCE1 Identified by GWASs Contribute to Gastric Adenocarcinoma Susceptibility in an Eastern Chinese Population
por: Wang, Mengyun, et al.
Publicado: (2012)

NTCP Deficiency Causes Gallbladder Abnormalities in Mice and Human Beings
por: Mao, Fengfeng, et al.
Publicado: (2020)

NTCP gene polymorphisms and hepatitis B virus infection status in a Ghanaian population
por: Nyarko, Eric, et al.
Publicado: (2020)

Mechanistic insights into the inhibition of NTCP by myrcludex B
por: Donkers, Joanne M., et al.
Publicado: (2019)

Insufficient evidence for NTCP activity in stellate cells
por: Kunst, Roni F, et al.
Publicado: (2022)

Common Variants in LRP2 and COMT Genes Affect the Susceptibility of Gout in a Chinese Population
por: Dong, Zheng, et al.
Publicado: (2015)

NTCP deficiency in mice protects against obesity and hepatosteatosis
por: Donkers, Joanne M., et al.
Publicado: (2019)

In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?
por: Giersch, Katja, et al.
Publicado: (2021)

Differences in lower cranial nerve complications predicted by the NTCP model between RTOG and reduced-volume IMRT planning in radiotherapy for nasopharyngeal carcinoma
por: Qian, Jianjun, et al.
Publicado: (2020)

Association of the GLB1 rs4678680 genetic variant with risk of HBV-related hepatocellular carcinoma
por: Wang, Wen-Tao, et al.
Publicado: (2016)

The status of HBV infection influences metastatic pattern and survival in Chinese patients with pancreatic cancer
por: Wei, Xiao-li, et al.
Publicado: (2013)

Incorporating NTCP into Randomized Trials of Proton Versus Photon Therapy
por: Scherman, Jonas, et al.
Publicado: (2019)

NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma
por: Mazonakis, Michalis, et al.
Publicado: (2023)

Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma
por: Chen, Yulong, et al.
Publicado: (2021)

A type-specific nested PCR assay established and applied for investigation of HBV genotype and subgenotype in Chinese patients with chronic HBV infection
por: Nie, Jing-Jing, et al.
Publicado: (2012)

Development of a normal tissue complication probability (NTCP) model for radiation-induced hypothyroidism in nasopharyngeal carcinoma patients
por: Luo, Ren, et al.
Publicado: (2018)

Genomic and transcriptome profiling identified both human and HBV genetic variations and their interactions in Chinese hepatocellular carcinoma
por: Dong, Hua, et al.
Publicado: (2015)

NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry
por: Watashi, Koichi, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_quh5eg4nksf7mtftfhrdf4knia