Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress

In this study, the vitamin D(3) plus nicotine (VDN) model of rats was used to prove that H(2)S alleviates vascular calcification (VC) and phenotype transformation of vascular smooth muscle cells (VSMC). Besides, H(2)S can also inhibit endoplasmic reticulum stress (ERS) of calcified aortic tissues. T...

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Detalles Bibliográficos
Autores principales: Yang, Rui, Teng, Xu, Li, Hui, Xue, Hong-Mei, Guo, Qi, Xiao, Lin, Wu, Yu-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789052/
https://www.ncbi.nlm.nih.gov/pubmed/27022436
http://dx.doi.org/10.1155/2016/9095242
Descripción
Sumario:In this study, the vitamin D(3) plus nicotine (VDN) model of rats was used to prove that H(2)S alleviates vascular calcification (VC) and phenotype transformation of vascular smooth muscle cells (VSMC). Besides, H(2)S can also inhibit endoplasmic reticulum stress (ERS) of calcified aortic tissues. The effect of H(2)S on alleviating VC and phenotype transformation of VSMC can be blocked by TM, while PBA also alleviated VC and phenotype transformation of VSMC that was similar to the effect of H(2)S. These results suggest that H(2)S may alleviate rat aorta VC by inhibiting ERS, providing new target and perspective for prevention and treatment of VC.

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