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Mendelian Randomization and Type 2 Diabetes
Type 2 diabetes (T2DM) is a common, complex disease that poses a substantial burden on individual and population health, but we have relatively limited understanding of its underlying pathophysiology. Observational studies have highlighted large numbers of risk factors for T2DM, some of which are mo...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer US
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789194/ https://www.ncbi.nlm.nih.gov/pubmed/26809778 http://dx.doi.org/10.1007/s10557-016-6638-5 |
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author | Swerdlow, Daniel I. |
author_facet | Swerdlow, Daniel I. |
author_sort | Swerdlow, Daniel I. |
collection | PubMed |
description | Type 2 diabetes (T2DM) is a common, complex disease that poses a substantial burden on individual and population health, but we have relatively limited understanding of its underlying pathophysiology. Observational studies have highlighted large numbers of risk factors for T2DM, some of which are modifiable through behavioural or pharmacological intervention. Determining which of these risk factors plays a causal role in the development of T2DM has been a challenge, but Mendelian randomisation (MR) studies are harnessing genetic data in population studies to offer new insights. Using evolving analytical methods, MR studies continue to address questions of causality related to T2DM, including exploring the roles of adiposity, blood lipids and inflammation. The causal roles of a number of important modifiable risk factors have been confirmed by MR studies, while the relevance of others has been called into question. As more MR studies are conducted, methods are developed and refined in order to make the most efficient and reliable use of available genetic and phenotypic data. In this review, the design and findings of some important MR studies related to T2DM are explored and their relevance for translation to clinical practice considered. |
format | Online Article Text |
id | pubmed-4789194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-47891942016-04-05 Mendelian Randomization and Type 2 Diabetes Swerdlow, Daniel I. Cardiovasc Drugs Ther Original Article Type 2 diabetes (T2DM) is a common, complex disease that poses a substantial burden on individual and population health, but we have relatively limited understanding of its underlying pathophysiology. Observational studies have highlighted large numbers of risk factors for T2DM, some of which are modifiable through behavioural or pharmacological intervention. Determining which of these risk factors plays a causal role in the development of T2DM has been a challenge, but Mendelian randomisation (MR) studies are harnessing genetic data in population studies to offer new insights. Using evolving analytical methods, MR studies continue to address questions of causality related to T2DM, including exploring the roles of adiposity, blood lipids and inflammation. The causal roles of a number of important modifiable risk factors have been confirmed by MR studies, while the relevance of others has been called into question. As more MR studies are conducted, methods are developed and refined in order to make the most efficient and reliable use of available genetic and phenotypic data. In this review, the design and findings of some important MR studies related to T2DM are explored and their relevance for translation to clinical practice considered. Springer US 2016-01-26 2016 /pmc/articles/PMC4789194/ /pubmed/26809778 http://dx.doi.org/10.1007/s10557-016-6638-5 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Swerdlow, Daniel I. Mendelian Randomization and Type 2 Diabetes |
title | Mendelian Randomization and Type 2 Diabetes |
title_full | Mendelian Randomization and Type 2 Diabetes |
title_fullStr | Mendelian Randomization and Type 2 Diabetes |
title_full_unstemmed | Mendelian Randomization and Type 2 Diabetes |
title_short | Mendelian Randomization and Type 2 Diabetes |
title_sort | mendelian randomization and type 2 diabetes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789194/ https://www.ncbi.nlm.nih.gov/pubmed/26809778 http://dx.doi.org/10.1007/s10557-016-6638-5 |
work_keys_str_mv | AT swerdlowdanieli mendelianrandomizationandtype2diabetes |