Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity

Aggregation and toxicity of the amyloid β-peptide (Aβ) are considered as critical events in the initiation and progression of Alzheimer’s disease (AD). Recent evidence indicated that soluble oligomeric Aβ assemblies exert pronounced toxicity, rather than larger fibrillar aggregates that deposit in t...

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Detalles Bibliográficos
Autores principales: Kumar, Sathish, Wirths, Oliver, Stüber, Kathrin, Wunderlich, Patrick, Koch, Philipp, Theil, Sandra, Rezaei-Ghaleh, Nasrollah, Zweckstetter, Markus, Bayer, Thomas A., Brüstle, Oliver, Thal, Dietmar R., Walter, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789232/
https://www.ncbi.nlm.nih.gov/pubmed/26898910
http://dx.doi.org/10.1007/s00401-016-1546-0

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