Cargando…

The possible meaning of fractional anisotropy measurement of the cervical spinal cord in correct diagnosis of amyotrophic lateral sclerosis

Diagnosis of amyotrophic lateral sclerosis (ALS) is based on clinical criteria and electrophysiological tests (electromyography, and transcranial magnetic stimulation). In the search for ALS biomarkers, the role of imaging procedures is currently emphasized, especially modern MR techniques. MR proce...

Descripción completa

Detalles Bibliográficos
Autores principales: Budrewicz, Slawomir, Szewczyk, Pawel, Bladowska, Joanna, Podemski, Ryszard, Koziorowska-Gawron, Ewa, Ejma, Maria, Słotwiński, Krzysztof, Koszewicz, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789300/
https://www.ncbi.nlm.nih.gov/pubmed/26590991
http://dx.doi.org/10.1007/s10072-015-2418-4
_version_ 1782420830601347072
author Budrewicz, Slawomir
Szewczyk, Pawel
Bladowska, Joanna
Podemski, Ryszard
Koziorowska-Gawron, Ewa
Ejma, Maria
Słotwiński, Krzysztof
Koszewicz, Magdalena
author_facet Budrewicz, Slawomir
Szewczyk, Pawel
Bladowska, Joanna
Podemski, Ryszard
Koziorowska-Gawron, Ewa
Ejma, Maria
Słotwiński, Krzysztof
Koszewicz, Magdalena
author_sort Budrewicz, Slawomir
collection PubMed
description Diagnosis of amyotrophic lateral sclerosis (ALS) is based on clinical criteria and electrophysiological tests (electromyography, and transcranial magnetic stimulation). In the search for ALS biomarkers, the role of imaging procedures is currently emphasized, especially modern MR techniques. MR procedures were performed on 15 ALS patients and a sex- and age-matched control group. The MR examinations were performed with a 1.5-T MR unit, and the protocol consisted of sagittal T1-weighed images, sagittal and axial T2-weighed images, and sagittal T2-weighed FAT SAT images followed by an axial diffusion tensor imaging (DTI) sequence of the cervical spinal cord. FA values in individual segments of the cervical spinal cord were decreased in the ALS group in comparison with the control group. After comparing FA values for anterior, posterior, and lateral corticospinal columns, the greatest difference was observed between the C2 and C5 segments. Spinal cord assessment with the use of FA measurements allows for confirmation of the motor pathways lesion in ALS patients. The method, together with clinical criteria, could be helpful in ALS diagnosis, assessment of clinical course, or even the effects of new drugs. The results also confirmed the theory of the generalized character of ALS.
format Online
Article
Text
id pubmed-4789300
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Springer Milan
record_format MEDLINE/PubMed
spelling pubmed-47893002016-04-09 The possible meaning of fractional anisotropy measurement of the cervical spinal cord in correct diagnosis of amyotrophic lateral sclerosis Budrewicz, Slawomir Szewczyk, Pawel Bladowska, Joanna Podemski, Ryszard Koziorowska-Gawron, Ewa Ejma, Maria Słotwiński, Krzysztof Koszewicz, Magdalena Neurol Sci Original Article Diagnosis of amyotrophic lateral sclerosis (ALS) is based on clinical criteria and electrophysiological tests (electromyography, and transcranial magnetic stimulation). In the search for ALS biomarkers, the role of imaging procedures is currently emphasized, especially modern MR techniques. MR procedures were performed on 15 ALS patients and a sex- and age-matched control group. The MR examinations were performed with a 1.5-T MR unit, and the protocol consisted of sagittal T1-weighed images, sagittal and axial T2-weighed images, and sagittal T2-weighed FAT SAT images followed by an axial diffusion tensor imaging (DTI) sequence of the cervical spinal cord. FA values in individual segments of the cervical spinal cord were decreased in the ALS group in comparison with the control group. After comparing FA values for anterior, posterior, and lateral corticospinal columns, the greatest difference was observed between the C2 and C5 segments. Spinal cord assessment with the use of FA measurements allows for confirmation of the motor pathways lesion in ALS patients. The method, together with clinical criteria, could be helpful in ALS diagnosis, assessment of clinical course, or even the effects of new drugs. The results also confirmed the theory of the generalized character of ALS. Springer Milan 2015-11-21 2016 /pmc/articles/PMC4789300/ /pubmed/26590991 http://dx.doi.org/10.1007/s10072-015-2418-4 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Budrewicz, Slawomir
Szewczyk, Pawel
Bladowska, Joanna
Podemski, Ryszard
Koziorowska-Gawron, Ewa
Ejma, Maria
Słotwiński, Krzysztof
Koszewicz, Magdalena
The possible meaning of fractional anisotropy measurement of the cervical spinal cord in correct diagnosis of amyotrophic lateral sclerosis
title The possible meaning of fractional anisotropy measurement of the cervical spinal cord in correct diagnosis of amyotrophic lateral sclerosis
title_full The possible meaning of fractional anisotropy measurement of the cervical spinal cord in correct diagnosis of amyotrophic lateral sclerosis
title_fullStr The possible meaning of fractional anisotropy measurement of the cervical spinal cord in correct diagnosis of amyotrophic lateral sclerosis
title_full_unstemmed The possible meaning of fractional anisotropy measurement of the cervical spinal cord in correct diagnosis of amyotrophic lateral sclerosis
title_short The possible meaning of fractional anisotropy measurement of the cervical spinal cord in correct diagnosis of amyotrophic lateral sclerosis
title_sort possible meaning of fractional anisotropy measurement of the cervical spinal cord in correct diagnosis of amyotrophic lateral sclerosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789300/
https://www.ncbi.nlm.nih.gov/pubmed/26590991
http://dx.doi.org/10.1007/s10072-015-2418-4
work_keys_str_mv AT budrewiczslawomir thepossiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT szewczykpawel thepossiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT bladowskajoanna thepossiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT podemskiryszard thepossiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT koziorowskagawronewa thepossiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT ejmamaria thepossiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT słotwinskikrzysztof thepossiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT koszewiczmagdalena thepossiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT budrewiczslawomir possiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT szewczykpawel possiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT bladowskajoanna possiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT podemskiryszard possiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT koziorowskagawronewa possiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT ejmamaria possiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT słotwinskikrzysztof possiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis
AT koszewiczmagdalena possiblemeaningoffractionalanisotropymeasurementofthecervicalspinalcordincorrectdiagnosisofamyotrophiclateralsclerosis