Cargando…
Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells
Dendritic cells present in the digestive tract are constantly exposed to environmental antigens, commensal flora, and invading pathogens. Under steady-state conditions, these cells have high tolerogenic potential, triggering differentiation of regulatory T cells to protect the host from unwanted pro...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789473/ https://www.ncbi.nlm.nih.gov/pubmed/27034589 http://dx.doi.org/10.1155/2016/3104727 |
_version_ | 1782420862760124416 |
---|---|
author | Aliberti, Julio |
author_facet | Aliberti, Julio |
author_sort | Aliberti, Julio |
collection | PubMed |
description | Dendritic cells present in the digestive tract are constantly exposed to environmental antigens, commensal flora, and invading pathogens. Under steady-state conditions, these cells have high tolerogenic potential, triggering differentiation of regulatory T cells to protect the host from unwanted proinflammatory immune responses to innocuous antigens or commensals. On the other hand, these cells must discriminate between commensal flora and invading pathogens and mount powerful immune response against pathogens. A potential result of unbalanced tolerogenic versus proinflammatory responses mediated by dendritic cells is associated with chronic inflammatory conditions, such as Crohn's disease, ulcerative colitis, food allergies, and celiac disease. Herein, we review the dendritic cell population involved in mediating tolerance and immunity in mucosal surfaces, the progress in unveiling their development in vivo, and factors that can influence their functions. |
format | Online Article Text |
id | pubmed-4789473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-47894732016-03-31 Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells Aliberti, Julio Mediators Inflamm Review Article Dendritic cells present in the digestive tract are constantly exposed to environmental antigens, commensal flora, and invading pathogens. Under steady-state conditions, these cells have high tolerogenic potential, triggering differentiation of regulatory T cells to protect the host from unwanted proinflammatory immune responses to innocuous antigens or commensals. On the other hand, these cells must discriminate between commensal flora and invading pathogens and mount powerful immune response against pathogens. A potential result of unbalanced tolerogenic versus proinflammatory responses mediated by dendritic cells is associated with chronic inflammatory conditions, such as Crohn's disease, ulcerative colitis, food allergies, and celiac disease. Herein, we review the dendritic cell population involved in mediating tolerance and immunity in mucosal surfaces, the progress in unveiling their development in vivo, and factors that can influence their functions. Hindawi Publishing Corporation 2016 2016-02-29 /pmc/articles/PMC4789473/ /pubmed/27034589 http://dx.doi.org/10.1155/2016/3104727 Text en Copyright © 2016 Julio Aliberti. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Aliberti, Julio Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells |
title | Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells |
title_full | Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells |
title_fullStr | Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells |
title_full_unstemmed | Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells |
title_short | Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells |
title_sort | immunity and tolerance induced by intestinal mucosal dendritic cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789473/ https://www.ncbi.nlm.nih.gov/pubmed/27034589 http://dx.doi.org/10.1155/2016/3104727 |
work_keys_str_mv | AT alibertijulio immunityandtoleranceinducedbyintestinalmucosaldendriticcells |