NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula

Little is known about Yu-Ping-Feng (YPF), a typical Chinese herbal decoction, for its antitumor efficacy in non-small-cell lung cancer (NSCLC). Here, we found that YPF significantly inhibited the growth of Lewis lung cancer, prolonged the survival of tumor-bearing mice, promoted NK cell tumor infilt...

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Autores principales: Luo, Yingbin, Wu, Jianchun, Zhu, Xiaowen, Gong, Chenyuan, Yao, Chao, Ni, Zhongya, Wang, Lixin, Ni, Lulu, Li, Yan, Zhu, Shiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789500/
https://www.ncbi.nlm.nih.gov/pubmed/27034590
http://dx.doi.org/10.1155/2016/3541283
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author Luo, Yingbin
Wu, Jianchun
Zhu, Xiaowen
Gong, Chenyuan
Yao, Chao
Ni, Zhongya
Wang, Lixin
Ni, Lulu
Li, Yan
Zhu, Shiguo
author_facet Luo, Yingbin
Wu, Jianchun
Zhu, Xiaowen
Gong, Chenyuan
Yao, Chao
Ni, Zhongya
Wang, Lixin
Ni, Lulu
Li, Yan
Zhu, Shiguo
author_sort Luo, Yingbin
collection PubMed
description Little is known about Yu-Ping-Feng (YPF), a typical Chinese herbal decoction, for its antitumor efficacy in non-small-cell lung cancer (NSCLC). Here, we found that YPF significantly inhibited the growth of Lewis lung cancer, prolonged the survival of tumor-bearing mice, promoted NK cell tumor infiltration, increased the population of NK cells in spleen, and enhanced NK cell-mediated killing activity. The growth suppression of tumors by YPF was significantly reversed by the depletion of NK cells. Furthermore, we found that YPF significantly downregulated the expression of TGF-β, indoleamine 2,3-dioxygenase, and IL-10 in tumor microenvironment. These results demonstrated that YPF has a NK cell-dependent inhibitory effect on Lewis lung cancer.
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spelling pubmed-47895002016-03-31 NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula Luo, Yingbin Wu, Jianchun Zhu, Xiaowen Gong, Chenyuan Yao, Chao Ni, Zhongya Wang, Lixin Ni, Lulu Li, Yan Zhu, Shiguo Mediators Inflamm Research Article Little is known about Yu-Ping-Feng (YPF), a typical Chinese herbal decoction, for its antitumor efficacy in non-small-cell lung cancer (NSCLC). Here, we found that YPF significantly inhibited the growth of Lewis lung cancer, prolonged the survival of tumor-bearing mice, promoted NK cell tumor infiltration, increased the population of NK cells in spleen, and enhanced NK cell-mediated killing activity. The growth suppression of tumors by YPF was significantly reversed by the depletion of NK cells. Furthermore, we found that YPF significantly downregulated the expression of TGF-β, indoleamine 2,3-dioxygenase, and IL-10 in tumor microenvironment. These results demonstrated that YPF has a NK cell-dependent inhibitory effect on Lewis lung cancer. Hindawi Publishing Corporation 2016 2016-02-29 /pmc/articles/PMC4789500/ /pubmed/27034590 http://dx.doi.org/10.1155/2016/3541283 Text en Copyright © 2016 Yingbin Luo et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Luo, Yingbin
Wu, Jianchun
Zhu, Xiaowen
Gong, Chenyuan
Yao, Chao
Ni, Zhongya
Wang, Lixin
Ni, Lulu
Li, Yan
Zhu, Shiguo
NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula
title NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula
title_full NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula
title_fullStr NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula
title_full_unstemmed NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula
title_short NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula
title_sort nk cell-dependent growth inhibition of lewis lung cancer by yu-ping-feng, an ancient chinese herbal formula
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789500/
https://www.ncbi.nlm.nih.gov/pubmed/27034590
http://dx.doi.org/10.1155/2016/3541283
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