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Effects of Propranolol, a β-noradrenergic Antagonist, on Memory Consolidation and Reconsolidation in Mice

Memory reconsolidation impairment using the β-noradrenergic receptor blocker propranolol is a promising novel treatment avenue for patients suffering from pathogenic memories, such as post-traumatic stress disorder (PTSD). However, in order to better inform targeted treatment development, the effect...

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Autores principales: Villain, Hélène, Benkahoul, Aïcha, Drougard, Anne, Lafragette, Marie, Muzotte, Elodie, Pech, Stéphane, Bui, Eric, Brunet, Alain, Birmes, Philippe, Roullet, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789536/
https://www.ncbi.nlm.nih.gov/pubmed/27014009
http://dx.doi.org/10.3389/fnbeh.2016.00049
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author Villain, Hélène
Benkahoul, Aïcha
Drougard, Anne
Lafragette, Marie
Muzotte, Elodie
Pech, Stéphane
Bui, Eric
Brunet, Alain
Birmes, Philippe
Roullet, Pascal
author_facet Villain, Hélène
Benkahoul, Aïcha
Drougard, Anne
Lafragette, Marie
Muzotte, Elodie
Pech, Stéphane
Bui, Eric
Brunet, Alain
Birmes, Philippe
Roullet, Pascal
author_sort Villain, Hélène
collection PubMed
description Memory reconsolidation impairment using the β-noradrenergic receptor blocker propranolol is a promising novel treatment avenue for patients suffering from pathogenic memories, such as post-traumatic stress disorder (PTSD). However, in order to better inform targeted treatment development, the effects of this compound on memory need to be better characterized via translational research. We examined the effects of systemic propranolol administration in mice undergoing a wide range of behavioral tests to determine more specifically which aspects of the memory consolidation and reconsolidation are impaired by propranolol. We found that propranolol (10 mg/kg) affected memory consolidation in non-aversive tasks (object recognition and object location) but not in moderately (Morris water maze (MWM) to highly (passive avoidance, conditioned taste aversion) aversive tasks. Further, propranolol impaired memory reconsolidation in the most and in the least aversive tasks, but not in the moderately aversive task, suggesting its amnesic effect was not related to task aversion. Moreover, in aquatic object recognition and location tasks in which animals were forced to behave (contrary to the classic versions of the tasks); propranolol did not impair memory reconsolidation. Taken together our results suggest that the memory impairment observed after propranolol administration may result from a modification of the emotional valence of the memory rather than a disruption of the contextual component of the memory trace. This is relevant to the use of propranolol to block memory reconsolidation in individuals with PTSD, as such a treatment would not erase the traumatic memory but only reduce the emotional valence associated with this event.
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spelling pubmed-47895362016-03-24 Effects of Propranolol, a β-noradrenergic Antagonist, on Memory Consolidation and Reconsolidation in Mice Villain, Hélène Benkahoul, Aïcha Drougard, Anne Lafragette, Marie Muzotte, Elodie Pech, Stéphane Bui, Eric Brunet, Alain Birmes, Philippe Roullet, Pascal Front Behav Neurosci Neuroscience Memory reconsolidation impairment using the β-noradrenergic receptor blocker propranolol is a promising novel treatment avenue for patients suffering from pathogenic memories, such as post-traumatic stress disorder (PTSD). However, in order to better inform targeted treatment development, the effects of this compound on memory need to be better characterized via translational research. We examined the effects of systemic propranolol administration in mice undergoing a wide range of behavioral tests to determine more specifically which aspects of the memory consolidation and reconsolidation are impaired by propranolol. We found that propranolol (10 mg/kg) affected memory consolidation in non-aversive tasks (object recognition and object location) but not in moderately (Morris water maze (MWM) to highly (passive avoidance, conditioned taste aversion) aversive tasks. Further, propranolol impaired memory reconsolidation in the most and in the least aversive tasks, but not in the moderately aversive task, suggesting its amnesic effect was not related to task aversion. Moreover, in aquatic object recognition and location tasks in which animals were forced to behave (contrary to the classic versions of the tasks); propranolol did not impair memory reconsolidation. Taken together our results suggest that the memory impairment observed after propranolol administration may result from a modification of the emotional valence of the memory rather than a disruption of the contextual component of the memory trace. This is relevant to the use of propranolol to block memory reconsolidation in individuals with PTSD, as such a treatment would not erase the traumatic memory but only reduce the emotional valence associated with this event. Frontiers Media S.A. 2016-03-14 /pmc/articles/PMC4789536/ /pubmed/27014009 http://dx.doi.org/10.3389/fnbeh.2016.00049 Text en Copyright © 2016 Villain, Benkahoul, Drougard, Lafragette, Muzotte, Pech, Bui, Brunet, Birmes and Roullet. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Villain, Hélène
Benkahoul, Aïcha
Drougard, Anne
Lafragette, Marie
Muzotte, Elodie
Pech, Stéphane
Bui, Eric
Brunet, Alain
Birmes, Philippe
Roullet, Pascal
Effects of Propranolol, a β-noradrenergic Antagonist, on Memory Consolidation and Reconsolidation in Mice
title Effects of Propranolol, a β-noradrenergic Antagonist, on Memory Consolidation and Reconsolidation in Mice
title_full Effects of Propranolol, a β-noradrenergic Antagonist, on Memory Consolidation and Reconsolidation in Mice
title_fullStr Effects of Propranolol, a β-noradrenergic Antagonist, on Memory Consolidation and Reconsolidation in Mice
title_full_unstemmed Effects of Propranolol, a β-noradrenergic Antagonist, on Memory Consolidation and Reconsolidation in Mice
title_short Effects of Propranolol, a β-noradrenergic Antagonist, on Memory Consolidation and Reconsolidation in Mice
title_sort effects of propranolol, a β-noradrenergic antagonist, on memory consolidation and reconsolidation in mice
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789536/
https://www.ncbi.nlm.nih.gov/pubmed/27014009
http://dx.doi.org/10.3389/fnbeh.2016.00049
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