Cytosolic Innate Immune Sensing and Signaling upon Infection

Cytosolic sensing of pathogens is essential to a productive immune response. Recent reports have emphasized the importance of signaling platforms emanating from organelles and cytosolic sensors, particularly during the response to intracellular pathogens. Here, we highlight recent discoveries identi...

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Detalles Bibliográficos
Autores principales: Radoshevich, Lilliana, Dussurget, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789553/
https://www.ncbi.nlm.nih.gov/pubmed/27014235
http://dx.doi.org/10.3389/fmicb.2016.00313
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author Radoshevich, Lilliana
Dussurget, Olivier
author_facet Radoshevich, Lilliana
Dussurget, Olivier
author_sort Radoshevich, Lilliana
collection PubMed
description Cytosolic sensing of pathogens is essential to a productive immune response. Recent reports have emphasized the importance of signaling platforms emanating from organelles and cytosolic sensors, particularly during the response to intracellular pathogens. Here, we highlight recent discoveries identifying the key mediators of nucleic acid and cyclic nucleotide sensing and discuss their importance in host defense. This review will also cover strategies evolved by pathogens to manipulate these pathways.
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spelling pubmed-47895532016-03-24 Cytosolic Innate Immune Sensing and Signaling upon Infection Radoshevich, Lilliana Dussurget, Olivier Front Microbiol Microbiology Cytosolic sensing of pathogens is essential to a productive immune response. Recent reports have emphasized the importance of signaling platforms emanating from organelles and cytosolic sensors, particularly during the response to intracellular pathogens. Here, we highlight recent discoveries identifying the key mediators of nucleic acid and cyclic nucleotide sensing and discuss their importance in host defense. This review will also cover strategies evolved by pathogens to manipulate these pathways. Frontiers Media S.A. 2016-03-14 /pmc/articles/PMC4789553/ /pubmed/27014235 http://dx.doi.org/10.3389/fmicb.2016.00313 Text en Copyright © 2016 Radoshevich and Dussurget. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Radoshevich, Lilliana
Dussurget, Olivier
Cytosolic Innate Immune Sensing and Signaling upon Infection
title Cytosolic Innate Immune Sensing and Signaling upon Infection
title_full Cytosolic Innate Immune Sensing and Signaling upon Infection
title_fullStr Cytosolic Innate Immune Sensing and Signaling upon Infection
title_full_unstemmed Cytosolic Innate Immune Sensing and Signaling upon Infection
title_short Cytosolic Innate Immune Sensing and Signaling upon Infection
title_sort cytosolic innate immune sensing and signaling upon infection
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789553/
https://www.ncbi.nlm.nih.gov/pubmed/27014235
http://dx.doi.org/10.3389/fmicb.2016.00313
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