Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

Rapamycin, an inhibitor of mTOR signaling, has been shown to reverse diastolic dysfunction in old mice in 10 weeks, highlighting its therapeutic potential for a poorly treatable condition. However, the mechanisms and temporal regulation of its cardiac benefits remain unclear. We show that improved d...

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Detalles Bibliográficos
Autores principales: Chiao, Ying Ann, Kolwicz, Stephen C., Basisty, Nathan, Gagnidze, Arni, Zhang, Julia, Gu, Haiwei, Djukovic, Danijel, Beyer, Richard P., Raftery, Daniel, MacCoss, Michael, Tian, Rong, Rabinovitch, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789585/
https://www.ncbi.nlm.nih.gov/pubmed/26872208

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