Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase

Mutants of lamin A cause diseases including the Hutchinson-Gilford progeria syndrome (HGPS) characterized by premature aging. Lamin A undergoes a series of processing reactions, including farnesylation and proteolytic cleavage of the farnesylated C-terminal domain. The role of cleavage is unknown bu...

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Detalles Bibliográficos
Autores principales: Moiseeva, Olga, Lopes-Paciencia, Stéphane, Huot, Geneviève, Lessard, Frédéric, Ferbeyre, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789588/
https://www.ncbi.nlm.nih.gov/pubmed/26922519

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