Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer

An essential feature of cancer is dysregulation of cell senescence and death. Renalase, a recently discovered secreted flavoprotein, provides cytoprotection against ischemic and toxic cellular injury by signaling through the PI3K-AKT and MAPK pathways. Here we show that renalase expression is increa...

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Detalles Bibliográficos
Autores principales: Guo, Xiaojia, Hollander, Lindsay, MacPherson, Douglas, Wang, Ling, Velazquez, Heino, Chang, John, Safirstein, Robert, Cha, Charles, Gorelick, Fred, Desir, Gary V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789641/
https://www.ncbi.nlm.nih.gov/pubmed/26972355
http://dx.doi.org/10.1038/srep22996

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