Cargando…
MIG6 is MEK-regulated and affects EGF-induced migration in mutant NRAS melanoma
Activating mutations in NRAS are frequent driver events in cutaneous melanoma. NRAS is a GTP-binding protein, whose most well-characterized downstream effector is RAF leading to activation of MEK-ERK1/2 signaling. While there are no FDA-approved targeted therapies for melanoma patients with a primar...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789776/ https://www.ncbi.nlm.nih.gov/pubmed/26967478 http://dx.doi.org/10.1016/j.jid.2015.11.012 |