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Using AAV vectors expressing the β(2)-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size

Anabolic β(2)-adrenoceptor (β(2)-AR) agonists have been proposed as therapeutics for treating muscle wasting but concerns regarding possible off-target effects have hampered their use. We investigated whether β(2)-AR-mediated signalling could be modulated in skeletal muscle via gene delivery to the...

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Detalles Bibliográficos
Autores principales:	Hagg, Adam, Colgan, Timothy D., Thomson, Rachel E., Qian, Hongwei, Lynch, Gordon S., Gregorevic, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789796/ https://www.ncbi.nlm.nih.gov/pubmed/26972746 http://dx.doi.org/10.1038/srep23042

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