The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon

OBJECTIVE: ATG16L1 is an autophagy gene known to control host immune responses to viruses and bacteria. Recently, a non-synonymous single-nucleotide polymorphism in ATG16L1 (Thr300Ala), previously identified as a risk factor in Crohn's disease (CD), was associated with more favourable clinical...

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Detalles Bibliográficos
Autores principales: Grimm, Wesley A, Messer, Jeannette S, Murphy, Stephen F, Nero, Thomas, Lodolce, James P, Weber, Christopher R, Logsdon, Mark F, Bartulis, Sarah, Sylvester, Brooke E, Springer, Amanda, Dougherty, Urszula, Niewold, Timothy B, Kupfer, Sonia S, Ellis, Nathan, Huo, Dezheng, Bissonnette, Marc, Boone, David L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Colon
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789828/
https://www.ncbi.nlm.nih.gov/pubmed/25645662
http://dx.doi.org/10.1136/gutjnl-2014-308735

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