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Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis

PURPOSE: Several molecular epidemiological studies have investigated the association between OPN rs11730582 C>T polymorphism and cancer risk, but the results are inconsistent. Hence, a meta-analysis was conducted to determine the association of this polymorphism with cancer risk. MATERIALS AND ME...

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Autores principales: He, Lanlan, Wang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789843/
https://www.ncbi.nlm.nih.gov/pubmed/27022284
http://dx.doi.org/10.2147/OTT.S94425
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author He, Lanlan
Wang, Yong
author_facet He, Lanlan
Wang, Yong
author_sort He, Lanlan
collection PubMed
description PURPOSE: Several molecular epidemiological studies have investigated the association between OPN rs11730582 C>T polymorphism and cancer risk, but the results are inconsistent. Hence, a meta-analysis was conducted to determine the association of this polymorphism with cancer risk. MATERIALS AND METHODS: The related articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases. Pooled odds ratios and 95% confidence intervals were calculated to evaluate the strength of the associations. A random-effects model or fixed-effects model was employed depending on the heterogeneity. RESULTS: A total of ten case-control studies involving 2,749 cancer cases and 3,398 controls were included in the meta-analysis. In overall analysis, OPN rs11730582 C.T polymorphism was not associated with cancer risk. In a stratified analysis by cancer type, no significant association was found between OPN rs11730582 C>T polymorphism and the risk of glioma, gastric cancer, and other cancers. CONCLUSION: This meta-analysis suggests that OPN rs11730582 C.T polymorphism is not associated with cancer susceptibility.
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spelling pubmed-47898432016-03-28 Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis He, Lanlan Wang, Yong Onco Targets Ther Original Research PURPOSE: Several molecular epidemiological studies have investigated the association between OPN rs11730582 C>T polymorphism and cancer risk, but the results are inconsistent. Hence, a meta-analysis was conducted to determine the association of this polymorphism with cancer risk. MATERIALS AND METHODS: The related articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases. Pooled odds ratios and 95% confidence intervals were calculated to evaluate the strength of the associations. A random-effects model or fixed-effects model was employed depending on the heterogeneity. RESULTS: A total of ten case-control studies involving 2,749 cancer cases and 3,398 controls were included in the meta-analysis. In overall analysis, OPN rs11730582 C.T polymorphism was not associated with cancer risk. In a stratified analysis by cancer type, no significant association was found between OPN rs11730582 C>T polymorphism and the risk of glioma, gastric cancer, and other cancers. CONCLUSION: This meta-analysis suggests that OPN rs11730582 C.T polymorphism is not associated with cancer susceptibility. Dove Medical Press 2016-03-07 /pmc/articles/PMC4789843/ /pubmed/27022284 http://dx.doi.org/10.2147/OTT.S94425 Text en © 2016 He and Wang. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
He, Lanlan
Wang, Yong
Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis
title Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis
title_full Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis
title_fullStr Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis
title_full_unstemmed Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis
title_short Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis
title_sort association of opn rs11730582 polymorphism with cancer risk: a meta-analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789843/
https://www.ncbi.nlm.nih.gov/pubmed/27022284
http://dx.doi.org/10.2147/OTT.S94425
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