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Exploratory Spatial Mapping of the Occurrence of Antimicrobial Resistance in E. coli in the Community

The use of antimicrobials over the past six decades has been associated with the emergence and dissemination of antimicrobial-resistant bacteria. To explore local geographical patterns in the occurrence of acquired antimicrobial resistance (AMR), AMR of E. coli causing urinary tract infections (UTI)...

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Autores principales: Galvin, Sandra, Bergin, Niall, Hennessy, Ronan, Hanahoe, Belinda, Murphy, Andrew W., Cormican, Martin, Vellinga, Akke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790267/
https://www.ncbi.nlm.nih.gov/pubmed/27029306
http://dx.doi.org/10.3390/antibiotics2030328
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author Galvin, Sandra
Bergin, Niall
Hennessy, Ronan
Hanahoe, Belinda
Murphy, Andrew W.
Cormican, Martin
Vellinga, Akke
author_facet Galvin, Sandra
Bergin, Niall
Hennessy, Ronan
Hanahoe, Belinda
Murphy, Andrew W.
Cormican, Martin
Vellinga, Akke
author_sort Galvin, Sandra
collection PubMed
description The use of antimicrobials over the past six decades has been associated with the emergence and dissemination of antimicrobial-resistant bacteria. To explore local geographical patterns in the occurrence of acquired antimicrobial resistance (AMR), AMR of E. coli causing urinary tract infections (UTI) in the community in the West of Ireland was mapped. All adult patients consulting with a suspected UTI in 22 general practices in the West of Ireland over a nine-month study period were requested to supply a urine sample. Those with a laboratory confirmed E. coli infection were included (n = 752) in the study. Antimicrobial susceptibility testing was performed by standardized disc diffusion. Patient addresses were geocoded. The diameters of the zone of inhibition of growth for trimethoprim (5 μg) and ciprofloxacin (5 μg) for the relevant isolate was mapped against the patient address using ArcGIS software. A series of maps illustrating spatial distribution of AMR in the West of Ireland were generated. The spatial data demonstrated a higher proportion of isolates with AMR from urban areas. Some rural areas also showed high levels of resistant E. coli. Our study is the first to demonstrate the feasibility of using a geographical information system (GIS) platform for routine visual geographical analysis of AMR data in Ireland. Routine presentation of AMR data in this format may be valuable in understanding AMR trends at a local level.
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spelling pubmed-47902672016-03-24 Exploratory Spatial Mapping of the Occurrence of Antimicrobial Resistance in E. coli in the Community Galvin, Sandra Bergin, Niall Hennessy, Ronan Hanahoe, Belinda Murphy, Andrew W. Cormican, Martin Vellinga, Akke Antibiotics (Basel) Article The use of antimicrobials over the past six decades has been associated with the emergence and dissemination of antimicrobial-resistant bacteria. To explore local geographical patterns in the occurrence of acquired antimicrobial resistance (AMR), AMR of E. coli causing urinary tract infections (UTI) in the community in the West of Ireland was mapped. All adult patients consulting with a suspected UTI in 22 general practices in the West of Ireland over a nine-month study period were requested to supply a urine sample. Those with a laboratory confirmed E. coli infection were included (n = 752) in the study. Antimicrobial susceptibility testing was performed by standardized disc diffusion. Patient addresses were geocoded. The diameters of the zone of inhibition of growth for trimethoprim (5 μg) and ciprofloxacin (5 μg) for the relevant isolate was mapped against the patient address using ArcGIS software. A series of maps illustrating spatial distribution of AMR in the West of Ireland were generated. The spatial data demonstrated a higher proportion of isolates with AMR from urban areas. Some rural areas also showed high levels of resistant E. coli. Our study is the first to demonstrate the feasibility of using a geographical information system (GIS) platform for routine visual geographical analysis of AMR data in Ireland. Routine presentation of AMR data in this format may be valuable in understanding AMR trends at a local level. MDPI 2013-07-01 /pmc/articles/PMC4790267/ /pubmed/27029306 http://dx.doi.org/10.3390/antibiotics2030328 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Galvin, Sandra
Bergin, Niall
Hennessy, Ronan
Hanahoe, Belinda
Murphy, Andrew W.
Cormican, Martin
Vellinga, Akke
Exploratory Spatial Mapping of the Occurrence of Antimicrobial Resistance in E. coli in the Community
title Exploratory Spatial Mapping of the Occurrence of Antimicrobial Resistance in E. coli in the Community
title_full Exploratory Spatial Mapping of the Occurrence of Antimicrobial Resistance in E. coli in the Community
title_fullStr Exploratory Spatial Mapping of the Occurrence of Antimicrobial Resistance in E. coli in the Community
title_full_unstemmed Exploratory Spatial Mapping of the Occurrence of Antimicrobial Resistance in E. coli in the Community
title_short Exploratory Spatial Mapping of the Occurrence of Antimicrobial Resistance in E. coli in the Community
title_sort exploratory spatial mapping of the occurrence of antimicrobial resistance in e. coli in the community
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790267/
https://www.ncbi.nlm.nih.gov/pubmed/27029306
http://dx.doi.org/10.3390/antibiotics2030328
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