A Review of Management of Clostridium difficile Infection: Primary and Recurrence

Clostridium difficile infection (CDI) is a potentially fatal illness, especially in the elderly and hospitalized individuals. The recurrence and rates of CDI are increasing. In addition, some cases of CDI are refractory to the currently available antibiotics. The search for improved modalities for t...

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Detalles Bibliográficos
Autores principales: Vincent, Yasmeen, Manji, Arif, Gregory-Miller, Kathleen, Lee, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790304/
https://www.ncbi.nlm.nih.gov/pubmed/27025632
http://dx.doi.org/10.3390/antibiotics4040411
Descripción
Sumario:Clostridium difficile infection (CDI) is a potentially fatal illness, especially in the elderly and hospitalized individuals. The recurrence and rates of CDI are increasing. In addition, some cases of CDI are refractory to the currently available antibiotics. The search for improved modalities for the management of primary and recurrent CDI is underway. This review discusses the current antibiotics, fecal microbiota transplantation (FMT) and other options such as immunotherapy and administration of non-toxigenic Clostridium difficile (CD) for the management of both primary and recurrent CDI.

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