Cargando…

The Antidepressant-like Effects of Estrogen-mediated Ghrelin

Ghrelin, one of the brain-gut peptides, stimulates food-intake. Recently, ghrelin has also shown to play an important role in depression treatment. However, the mechanism of ghrelin’s antidepressant-like actions is unknown. On the other hand, sex differences in depression, and the fluctuation of est...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Pu, Liu, Changhong, Liu, Lei, Zhang, Xingyi, Ren, Bingzhong, Li, Bingjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790402/
https://www.ncbi.nlm.nih.gov/pubmed/26412072
http://dx.doi.org/10.2174/1570159X1304150831120650
_version_ 1782420987213512704
author Wang, Pu
Liu, Changhong
Liu, Lei
Zhang, Xingyi
Ren, Bingzhong
Li, Bingjin
author_facet Wang, Pu
Liu, Changhong
Liu, Lei
Zhang, Xingyi
Ren, Bingzhong
Li, Bingjin
author_sort Wang, Pu
collection PubMed
description Ghrelin, one of the brain-gut peptides, stimulates food-intake. Recently, ghrelin has also shown to play an important role in depression treatment. However, the mechanism of ghrelin’s antidepressant-like actions is unknown. On the other hand, sex differences in depression, and the fluctuation of estrogens secretion have been proved to play a key role in depression. It has been reported that women have higher level of ghrelin expression, and ghrelin can stimulate estrogen secretion while estrogen acts as a positive feedback mechanism to up-regulate ghrelin level. Ghrelin may be a potential regulator of reproductive function, and estrogen may have additional effect in ghrelin’s antidepressantlike actions. In this review, we summarize antidepressant-like effects of ghrelin and estrogen in basic and clinical studies, and provide new insight on ghrelin’s effect in depression.
format Online
Article
Text
id pubmed-4790402
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Bentham Science Publishers
record_format MEDLINE/PubMed
spelling pubmed-47904022016-04-04 The Antidepressant-like Effects of Estrogen-mediated Ghrelin Wang, Pu Liu, Changhong Liu, Lei Zhang, Xingyi Ren, Bingzhong Li, Bingjin Curr Neuropharmacol Article Ghrelin, one of the brain-gut peptides, stimulates food-intake. Recently, ghrelin has also shown to play an important role in depression treatment. However, the mechanism of ghrelin’s antidepressant-like actions is unknown. On the other hand, sex differences in depression, and the fluctuation of estrogens secretion have been proved to play a key role in depression. It has been reported that women have higher level of ghrelin expression, and ghrelin can stimulate estrogen secretion while estrogen acts as a positive feedback mechanism to up-regulate ghrelin level. Ghrelin may be a potential regulator of reproductive function, and estrogen may have additional effect in ghrelin’s antidepressantlike actions. In this review, we summarize antidepressant-like effects of ghrelin and estrogen in basic and clinical studies, and provide new insight on ghrelin’s effect in depression. Bentham Science Publishers 2015-07 2015-07 /pmc/articles/PMC4790402/ /pubmed/26412072 http://dx.doi.org/10.2174/1570159X1304150831120650 Text en ©2015 Bentham Science Publishers http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Wang, Pu
Liu, Changhong
Liu, Lei
Zhang, Xingyi
Ren, Bingzhong
Li, Bingjin
The Antidepressant-like Effects of Estrogen-mediated Ghrelin
title The Antidepressant-like Effects of Estrogen-mediated Ghrelin
title_full The Antidepressant-like Effects of Estrogen-mediated Ghrelin
title_fullStr The Antidepressant-like Effects of Estrogen-mediated Ghrelin
title_full_unstemmed The Antidepressant-like Effects of Estrogen-mediated Ghrelin
title_short The Antidepressant-like Effects of Estrogen-mediated Ghrelin
title_sort antidepressant-like effects of estrogen-mediated ghrelin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790402/
https://www.ncbi.nlm.nih.gov/pubmed/26412072
http://dx.doi.org/10.2174/1570159X1304150831120650
work_keys_str_mv AT wangpu theantidepressantlikeeffectsofestrogenmediatedghrelin
AT liuchanghong theantidepressantlikeeffectsofestrogenmediatedghrelin
AT liulei theantidepressantlikeeffectsofestrogenmediatedghrelin
AT zhangxingyi theantidepressantlikeeffectsofestrogenmediatedghrelin
AT renbingzhong theantidepressantlikeeffectsofestrogenmediatedghrelin
AT libingjin theantidepressantlikeeffectsofestrogenmediatedghrelin
AT wangpu antidepressantlikeeffectsofestrogenmediatedghrelin
AT liuchanghong antidepressantlikeeffectsofestrogenmediatedghrelin
AT liulei antidepressantlikeeffectsofestrogenmediatedghrelin
AT zhangxingyi antidepressantlikeeffectsofestrogenmediatedghrelin
AT renbingzhong antidepressantlikeeffectsofestrogenmediatedghrelin
AT libingjin antidepressantlikeeffectsofestrogenmediatedghrelin