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The Antidepressant-like Effects of Estrogen-mediated Ghrelin
Ghrelin, one of the brain-gut peptides, stimulates food-intake. Recently, ghrelin has also shown to play an important role in depression treatment. However, the mechanism of ghrelin’s antidepressant-like actions is unknown. On the other hand, sex differences in depression, and the fluctuation of est...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Science Publishers
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790402/ https://www.ncbi.nlm.nih.gov/pubmed/26412072 http://dx.doi.org/10.2174/1570159X1304150831120650 |
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author | Wang, Pu Liu, Changhong Liu, Lei Zhang, Xingyi Ren, Bingzhong Li, Bingjin |
author_facet | Wang, Pu Liu, Changhong Liu, Lei Zhang, Xingyi Ren, Bingzhong Li, Bingjin |
author_sort | Wang, Pu |
collection | PubMed |
description | Ghrelin, one of the brain-gut peptides, stimulates food-intake. Recently, ghrelin has also shown to play an important role in depression treatment. However, the mechanism of ghrelin’s antidepressant-like actions is unknown. On the other hand, sex differences in depression, and the fluctuation of estrogens secretion have been proved to play a key role in depression. It has been reported that women have higher level of ghrelin expression, and ghrelin can stimulate estrogen secretion while estrogen acts as a positive feedback mechanism to up-regulate ghrelin level. Ghrelin may be a potential regulator of reproductive function, and estrogen may have additional effect in ghrelin’s antidepressantlike actions. In this review, we summarize antidepressant-like effects of ghrelin and estrogen in basic and clinical studies, and provide new insight on ghrelin’s effect in depression. |
format | Online Article Text |
id | pubmed-4790402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-47904022016-04-04 The Antidepressant-like Effects of Estrogen-mediated Ghrelin Wang, Pu Liu, Changhong Liu, Lei Zhang, Xingyi Ren, Bingzhong Li, Bingjin Curr Neuropharmacol Article Ghrelin, one of the brain-gut peptides, stimulates food-intake. Recently, ghrelin has also shown to play an important role in depression treatment. However, the mechanism of ghrelin’s antidepressant-like actions is unknown. On the other hand, sex differences in depression, and the fluctuation of estrogens secretion have been proved to play a key role in depression. It has been reported that women have higher level of ghrelin expression, and ghrelin can stimulate estrogen secretion while estrogen acts as a positive feedback mechanism to up-regulate ghrelin level. Ghrelin may be a potential regulator of reproductive function, and estrogen may have additional effect in ghrelin’s antidepressantlike actions. In this review, we summarize antidepressant-like effects of ghrelin and estrogen in basic and clinical studies, and provide new insight on ghrelin’s effect in depression. Bentham Science Publishers 2015-07 2015-07 /pmc/articles/PMC4790402/ /pubmed/26412072 http://dx.doi.org/10.2174/1570159X1304150831120650 Text en ©2015 Bentham Science Publishers http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Wang, Pu Liu, Changhong Liu, Lei Zhang, Xingyi Ren, Bingzhong Li, Bingjin The Antidepressant-like Effects of Estrogen-mediated Ghrelin |
title | The Antidepressant-like Effects of Estrogen-mediated Ghrelin |
title_full | The Antidepressant-like Effects of Estrogen-mediated Ghrelin |
title_fullStr | The Antidepressant-like Effects of Estrogen-mediated Ghrelin |
title_full_unstemmed | The Antidepressant-like Effects of Estrogen-mediated Ghrelin |
title_short | The Antidepressant-like Effects of Estrogen-mediated Ghrelin |
title_sort | antidepressant-like effects of estrogen-mediated ghrelin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790402/ https://www.ncbi.nlm.nih.gov/pubmed/26412072 http://dx.doi.org/10.2174/1570159X1304150831120650 |
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