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Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation
Theory of mind–the ability to decode and reason about others’ mental states–is a universal human skill and forms the basis of social cognition. Theory of mind accuracy is impaired in clinical conditions evidencing social impairment, including major depressive disorder. The current study is a prelimi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790964/ https://www.ncbi.nlm.nih.gov/pubmed/26974654 http://dx.doi.org/10.1371/journal.pone.0150872 |
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author | Zahavi, Arielle Y. Sabbagh, Mark A. Washburn, Dustin Mazurka, Raegan Bagby, R. Michael Strauss, John Kennedy, James L. Ravindran, Arun Harkness, Kate L. |
author_facet | Zahavi, Arielle Y. Sabbagh, Mark A. Washburn, Dustin Mazurka, Raegan Bagby, R. Michael Strauss, John Kennedy, James L. Ravindran, Arun Harkness, Kate L. |
author_sort | Zahavi, Arielle Y. |
collection | PubMed |
description | Theory of mind–the ability to decode and reason about others’ mental states–is a universal human skill and forms the basis of social cognition. Theory of mind accuracy is impaired in clinical conditions evidencing social impairment, including major depressive disorder. The current study is a preliminary investigation of the association of polymorphisms of the serotonin transporter (SLC6A4), dopamine transporter (DAT1), dopamine receptor D4 (DRD4), and catechol-O-methyl transferase (COMT) genes with theory of mind decoding in a sample of adults with major depression. Ninety-six young adults (38 depressed, 58 non-depressed) completed the ‘Reading the Mind in the Eyes task’ and a non-mentalistic control task. Genetic associations were only found for the depressed group. Specifically, superior accuracy in decoding mental states of a positive valence was seen in those homozygous for the long allele of the serotonin transporter gene, 9-allele carriers of DAT1, and long-allele carriers of DRD4. In contrast, superior accuracy in decoding mental states of a negative valence was seen in short-allele carriers of the serotonin transporter gene and 10/10 homozygotes of DAT1. Results are discussed in terms of their implications for integrating social cognitive and neurobiological models of etiology in major depression. |
format | Online Article Text |
id | pubmed-4790964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47909642016-03-23 Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation Zahavi, Arielle Y. Sabbagh, Mark A. Washburn, Dustin Mazurka, Raegan Bagby, R. Michael Strauss, John Kennedy, James L. Ravindran, Arun Harkness, Kate L. PLoS One Research Article Theory of mind–the ability to decode and reason about others’ mental states–is a universal human skill and forms the basis of social cognition. Theory of mind accuracy is impaired in clinical conditions evidencing social impairment, including major depressive disorder. The current study is a preliminary investigation of the association of polymorphisms of the serotonin transporter (SLC6A4), dopamine transporter (DAT1), dopamine receptor D4 (DRD4), and catechol-O-methyl transferase (COMT) genes with theory of mind decoding in a sample of adults with major depression. Ninety-six young adults (38 depressed, 58 non-depressed) completed the ‘Reading the Mind in the Eyes task’ and a non-mentalistic control task. Genetic associations were only found for the depressed group. Specifically, superior accuracy in decoding mental states of a positive valence was seen in those homozygous for the long allele of the serotonin transporter gene, 9-allele carriers of DAT1, and long-allele carriers of DRD4. In contrast, superior accuracy in decoding mental states of a negative valence was seen in short-allele carriers of the serotonin transporter gene and 10/10 homozygotes of DAT1. Results are discussed in terms of their implications for integrating social cognitive and neurobiological models of etiology in major depression. Public Library of Science 2016-03-14 /pmc/articles/PMC4790964/ /pubmed/26974654 http://dx.doi.org/10.1371/journal.pone.0150872 Text en © 2016 Zahavi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Zahavi, Arielle Y. Sabbagh, Mark A. Washburn, Dustin Mazurka, Raegan Bagby, R. Michael Strauss, John Kennedy, James L. Ravindran, Arun Harkness, Kate L. Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation |
title | Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation |
title_full | Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation |
title_fullStr | Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation |
title_full_unstemmed | Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation |
title_short | Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation |
title_sort | serotonin and dopamine gene variation and theory of mind decoding accuracy in major depression: a preliminary investigation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790964/ https://www.ncbi.nlm.nih.gov/pubmed/26974654 http://dx.doi.org/10.1371/journal.pone.0150872 |
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