Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma

Despite intensive study, many mysteries remain about the MYCN oncogene's functions. Here we focus on MYCN's role in neuroblastoma, the most common extracranial childhood cancer. MYCN gene amplification occurs in 20% of cases, but other recurrent somatic mutations are rare. This scarcity of...

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Detalles Bibliográficos
Autores principales: Duffy, David J., Krstic, Aleksandar, Halasz, Melinda, Schwarzl, Thomas, Fey, Dirk, Iljin, Kristiina, Mehta, Jai Prakash, Killick, Kate, Whilde, Jenny, Turriziani, Benedetta, Haapa-Paananen, Saija, Fey, Vidal, Fischer, Matthias, Westermann, Frank, Henrich, Kai-Oliver, Bannert, Steffen, Higgins, Desmond G., Kolch, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791225/
https://www.ncbi.nlm.nih.gov/pubmed/26673823

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