Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis

Activated in response to chemotherapy, senescence is a tumor suppressive mechanism that induces a permanent loss of proliferation. However, in response to treatment, it is not really known how cells can escape senescence and how irreversible or incomplete this pathway is. We have recently described...

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Detalles Bibliográficos
Autores principales: Vétillard, Alexandra, Jonchère, Barbara, Moreau, Marie, Toutain, Bertrand, Henry, Cécile, Fontanel, Simon, Bernard, Anne-Charlotte, Campone, Mario, Guette, Catherine, Coqueret, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791236/
https://www.ncbi.nlm.nih.gov/pubmed/26485768

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