Cargando…

VHL-dependent alterations in the secretome of renal cell carcinoma: Association with immune cell response?

Secreted proteins could modulate the interaction between tumor, stroma and immune cells within the tumor microenvironment thereby mounting an immunosuppressive tumor microenvironment. In order to determine the secretome-mediated, von Hippel Lindau (VHL)-regulated cross-talk between tumor cells and T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stehle, Franziska, Leisz, Sandra, Schulz, Kristin, Schwurack, Nicolle, Weber, Nico, Massa, Chiara, Kalich, Jana, Fahldieck, Corinna, Seliger, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791241/ https://www.ncbi.nlm.nih.gov/pubmed/26486078

Ejemplares similares

Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism
por: Leisz, Sandra, et al.
Publicado: (2015)

Identification of patient-specific and tumor-shared T cell receptor sequences in renal cell carcinoma patients
por: Massa, Chiara, et al.
Publicado: (2017)

Evaluation of TCR amplification in tumor lesions and peripheral blood of renal cell carcinoma patients
por: Massa, Chiara, et al.
Publicado: (2013)

Linking CREB function with altered metabolism in murine fibroblast-based model cell lines
por: Steven, André, et al.
Publicado: (2017)

Biglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells
por: Subbarayan, Karthikeyan, et al.
Publicado: (2022)

Determination of the consequences of VHL mutations on VHL transcripts in renal cell carcinoma
por: TAYLOR, CLAIRE, et al.
Publicado: (2012)

Deciphering von Hippel-Lindau (VHL/Vhl)-Associated Pancreatic Manifestations by Inactivating Vhl in Specific Pancreatic Cell Populations
por: Shen, H.-C. Jennifer, et al.
Publicado: (2009)

CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma
por: McRonald, Fiona E, et al.
Publicado: (2009)

Hypoxia-mediated alterations and their role in the HER-2/neuregulated CREB status and localization
por: Steven, André, et al.
Publicado: (2016)

Physoxia alters human mesenchymal stem cell secretome
por: Merkhan, Marwan M, et al.
Publicado: (2021)

Enhanced function of vaccine dendritic cells from obese donors upon inhibition of the lipid metabolism
por: Massa, Chiara, et al.
Publicado: (2022)

The Dark Side of Dendritic Cells: Development and Exploitation of Tolerogenic Activity That Favor Tumor Outgrowth and Immune Escape
por: Seliger, Barbara, et al.
Publicado: (2013)

Exofucosylation of Adipose Mesenchymal Stromal Cells Alters Their Secretome Profile
por: García-Bernal, David, et al.
Publicado: (2020)

Oncolytic Virus Therapy Alters the Secretome of Targeted Glioblastoma Cells
por: Godlewski, Jakub, et al.
Publicado: (2021)

Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review
por: Kim, Hyeong Su, et al.
Publicado: (2018)

Interferons and Resistance Mechanisms in Tumors and Pathogen-Driven Diseases—Focus on the Major Histocompatibility Complex (MHC) Antigen Processing Pathway
por: Massa, Chiara, et al.
Publicado: (2023)

The Most Common VHL Point Mutation R167Q in Hereditary VHL Disease Interferes with Cell Plasticity Regulation
por: Buart, Stéphanie, et al.
Publicado: (2021)

Identification of 3 novel VHL germ-line mutations in Danish VHL patients
por: Dandanell, Mette, et al.
Publicado: (2012)

VHL-deficiency leads to reductive stress in renal cells
por: Vellama, Hans, et al.
Publicado: (2023)

Prognostic and predictive value of VHL gene alteration in renal cell carcinoma: a meta-analysis and review
por: Kim, Bum Jun, et al.
Publicado: (2017)

Loss of Vhl alters trabecular bone loss during S. aureus osteomyelitis in a cell-specific manner
por: Ford, Caleb A., et al.
Publicado: (2022)

Role of miRs in immune suppression
por: Seliger, Barbara, et al.
Publicado: (2014)

VHL L169P Variant Does Not Alter Cellular Hypoxia Tension in Clear Cell Renal Cell Carcinoma
por: Hu, Junhui, et al.
Publicado: (2023)

Multi-Omics Profiling to Assess Signaling Changes upon VHL Restoration and Identify Putative VHL Substrates in Clear Cell Renal Cell Carcinoma Cell Lines
por: Wang, Xuechun, et al.
Publicado: (2022)

Computational and Experimental Characterization of dVHL Establish a Drosophila Model of VHL Syndrome
por: Shmueli, Merav D., et al.
Publicado: (2014)

VHL-P138R and VHL-L163R Novel Variants: Mechanisms of VHL Pathogenicity Involving HIF-Dependent and HIF-Independent Actions
por: Mathó, Cecilia, et al.
Publicado: (2022)

Somatic VHL gene alterations in MEN2-associated medullary thyroid carcinoma
por: Koch, Christian A, et al.
Publicado: (2006)

Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors
por: Moore, Lee E., et al.
Publicado: (2011)

Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation
por: Peri, Suraj, et al.
Publicado: (2016)

Analysis of the Secretomes of Paracoccidioides Mycelia and Yeast Cells
por: Weber, Simone Schneider, et al.
Publicado: (2012)

Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance
por: Razafinjatovo, Caroline, et al.
Publicado: (2016)

Inflammation Alters the Secretome and Immunomodulatory Properties of Human Skin-Derived Precursor Cells
por: De Kock, Joery, et al.
Publicado: (2020)

The Regenerative Role of the Fetal and Adult Stem Cell Secretome
por: Bollini, Sveva, et al.
Publicado: (2013)

Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma
por: Hu, Junhui, et al.
Publicado: (2023)

Genomic copy number alterations in clear cell renal carcinoma: associations with case characteristics and mechanisms of VHL gene inactivation
por: Moore, L E, et al.
Publicado: (2012)

Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma
por: Patard, J-J, et al.
Publicado: (2009)

Loss of VHL in RCC Reduces Repair and Alters Cellular Response to Benzo[a]pyrene
por: Schults, Marten A., et al.
Publicado: (2013)

Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations
por: Smestad, John A., et al.
Publicado: (2019)

THU494 VHL Protein Deficiency Alters The Immune Microenvironment Of Pancreatic Neuroendocrine Neoplasms
por: Chmelnik, Adiel, et al.
Publicado: (2023)

Loss of Von Hippel–Lindau (VHL) Tumor Suppressor Gene Function: VHL–HIF Pathway and Advances in Treatments for Metastatic Renal Cell Carcinoma (RCC)
por: Kim, Hyunho, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_flrfunjcudjcpd60h6oh394k0a