5-Fluorouracil-induced RNA stress engages a TRAIL-DISC-dependent apoptosis axis facilitated by p53

Despite recent advances in targeted therapeutics, administration of 5-fluorouracil (5-FU) remains a common clinical strategy for post-surgical treatment of solid tumors. Although it has been proposed that RNA metabolism is disturbed by 5-FU treatment, the key cytotoxic response is believed to be enz...

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Detalles Bibliográficos
Autores principales: Akpinar, Birce, Bracht, Ethiene V., Reijnders, Dorin, Safarikova, Barbora, Jelinkova, Iva, Grandien, Alf, Vaculova, Alena Hyrslova, Zhivotovsky, Boris, Olsson, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791259/
https://www.ncbi.nlm.nih.gov/pubmed/26544897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791259/
https://www.ncbi.nlm.nih.gov/pubmed/26544897

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