The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma

miRNAs are a group of small RNAs that have been reported to play a key role at each stage of tumorigenesis and are believed to have future practical value. We now demonstrate that Bim, which stimulates cell apoptosis, is obviously down-regulated in pancreatic cancer (PaC) tissues and cell lines. And...

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Detalles Bibliográficos
Autores principales: Liu, Rui, Zhang, Haiyang, Wang, Xia, Zhou, Likun, Li, Hongli, Deng, Ting, Qu, Yanjun, Duan, Jingjing, Bai, Ming, Ge, Shaohua, Ning, Tao, Zhang, Le, Huang, Dingzhi, Ba, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791270/
https://www.ncbi.nlm.nih.gov/pubmed/26517093
Descripción
Sumario:miRNAs are a group of small RNAs that have been reported to play a key role at each stage of tumorigenesis and are believed to have future practical value. We now demonstrate that Bim, which stimulates cell apoptosis, is obviously down-regulated in pancreatic cancer (PaC) tissues and cell lines. And Bim-related miR-24 is significantly up-regulated in PaC. The repressed expression of Bim is proved to be a result of miR-24, thus promoting cell growth of both cancer and vascular cells, and accelerating vascular ring formation. By using mouse tumor model, we clearly showed that miR-24 promotes tumor growth and angiogenesis by suppressing Bim expression in vivo. Therefore, a new pathway comprising miR-24 and Bim can be used in the exploration of drug-target therapy of PaC.

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