The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma

miRNAs are a group of small RNAs that have been reported to play a key role at each stage of tumorigenesis and are believed to have future practical value. We now demonstrate that Bim, which stimulates cell apoptosis, is obviously down-regulated in pancreatic cancer (PaC) tissues and cell lines. And...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Rui, Zhang, Haiyang, Wang, Xia, Zhou, Likun, Li, Hongli, Deng, Ting, Qu, Yanjun, Duan, Jingjing, Bai, Ming, Ge, Shaohua, Ning, Tao, Zhang, Le, Huang, Dingzhi, Ba, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791270/
https://www.ncbi.nlm.nih.gov/pubmed/26517093
_version_ 1782421059016851456
author Liu, Rui
Zhang, Haiyang
Wang, Xia
Zhou, Likun
Li, Hongli
Deng, Ting
Qu, Yanjun
Duan, Jingjing
Bai, Ming
Ge, Shaohua
Ning, Tao
Zhang, Le
Huang, Dingzhi
Ba, Yi
author_facet Liu, Rui
Zhang, Haiyang
Wang, Xia
Zhou, Likun
Li, Hongli
Deng, Ting
Qu, Yanjun
Duan, Jingjing
Bai, Ming
Ge, Shaohua
Ning, Tao
Zhang, Le
Huang, Dingzhi
Ba, Yi
author_sort Liu, Rui
collection PubMed
description miRNAs are a group of small RNAs that have been reported to play a key role at each stage of tumorigenesis and are believed to have future practical value. We now demonstrate that Bim, which stimulates cell apoptosis, is obviously down-regulated in pancreatic cancer (PaC) tissues and cell lines. And Bim-related miR-24 is significantly up-regulated in PaC. The repressed expression of Bim is proved to be a result of miR-24, thus promoting cell growth of both cancer and vascular cells, and accelerating vascular ring formation. By using mouse tumor model, we clearly showed that miR-24 promotes tumor growth and angiogenesis by suppressing Bim expression in vivo. Therefore, a new pathway comprising miR-24 and Bim can be used in the exploration of drug-target therapy of PaC.
format Online
Article
Text
id pubmed-4791270
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-47912702016-03-28 The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma Liu, Rui Zhang, Haiyang Wang, Xia Zhou, Likun Li, Hongli Deng, Ting Qu, Yanjun Duan, Jingjing Bai, Ming Ge, Shaohua Ning, Tao Zhang, Le Huang, Dingzhi Ba, Yi Oncotarget Research Paper miRNAs are a group of small RNAs that have been reported to play a key role at each stage of tumorigenesis and are believed to have future practical value. We now demonstrate that Bim, which stimulates cell apoptosis, is obviously down-regulated in pancreatic cancer (PaC) tissues and cell lines. And Bim-related miR-24 is significantly up-regulated in PaC. The repressed expression of Bim is proved to be a result of miR-24, thus promoting cell growth of both cancer and vascular cells, and accelerating vascular ring formation. By using mouse tumor model, we clearly showed that miR-24 promotes tumor growth and angiogenesis by suppressing Bim expression in vivo. Therefore, a new pathway comprising miR-24 and Bim can be used in the exploration of drug-target therapy of PaC. Impact Journals LLC 2015-10-28 /pmc/articles/PMC4791270/ /pubmed/26517093 Text en Copyright: © 2015 Liu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Liu, Rui
Zhang, Haiyang
Wang, Xia
Zhou, Likun
Li, Hongli
Deng, Ting
Qu, Yanjun
Duan, Jingjing
Bai, Ming
Ge, Shaohua
Ning, Tao
Zhang, Le
Huang, Dingzhi
Ba, Yi
The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma
title The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma
title_full The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma
title_fullStr The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma
title_full_unstemmed The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma
title_short The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma
title_sort mir-24-bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791270/
https://www.ncbi.nlm.nih.gov/pubmed/26517093
work_keys_str_mv AT liurui themir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT zhanghaiyang themir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT wangxia themir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT zhoulikun themir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT lihongli themir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT dengting themir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT quyanjun themir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT duanjingjing themir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT baiming themir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT geshaohua themir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT ningtao themir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT zhangle themir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT huangdingzhi themir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT bayi themir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT liurui mir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT zhanghaiyang mir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT wangxia mir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT zhoulikun mir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT lihongli mir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT dengting mir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT quyanjun mir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT duanjingjing mir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT baiming mir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT geshaohua mir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT ningtao mir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT zhangle mir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT huangdingzhi mir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma
AT bayi mir24bimpathwaypromotestumorgrowthandangiogenesisinpancreaticcarcinoma

Ejemplares similares