The ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells

As part of an anti-cancer natural product drug discovery program, we recently identified eusynstyelamide B (EB), which displayed cytotoxicity against MDA-MB-231 breast cancer cells (IC(50) = 5 μM) and induced apoptosis. Here, we investigated the mechanism of action of EB in cancer cell lines of the...

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Detalles Bibliográficos
Autores principales: Liberio, Michelle S., Sadowski, Martin C., Davis, Rohan A., Rockstroh, Anja, Vasireddy, Raj, Lehman, Melanie L., Nelson, Colleen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791278/
https://www.ncbi.nlm.nih.gov/pubmed/26733491

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