Cell Therapy for Parkinson’s Disease

In Parkinson’s disease (PD), dopamine neurons in the substantia nigra are degenerated and lost. Cell therapy for PD replaces the lost dopamine neurons by transplanting donor dopamine neural progenitor cells. Cell therapy for PD has been performed in the clinic since the 1980s and uses donor cells fr...

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Detalles Bibliográficos
Autores principales: MORIZANE, Asuka, TAKAHASHI, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Neurosurgical Society 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791304/
https://www.ncbi.nlm.nih.gov/pubmed/26912295
http://dx.doi.org/10.2176/nmc.ra.2015-0303
Descripción
Sumario:In Parkinson’s disease (PD), dopamine neurons in the substantia nigra are degenerated and lost. Cell therapy for PD replaces the lost dopamine neurons by transplanting donor dopamine neural progenitor cells. Cell therapy for PD has been performed in the clinic since the 1980s and uses donor cells from the mesencephalon of aborted embryos. Regenerative medicine for PD using induced pluripotent stem (iPS) cell technology is drawing attention, because it offers a limitless and more advantageous source of donor cells than aborted embryos.

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