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KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons

Increased phosphorylation of the KIF5 anterograde motor is associated with impaired axonal transport and neurodegeneration, but paradoxically also with normal transport, though the details are not fully defined. JNK phosphorylates KIF5C on S176 in the motor domain; a site that we show is phosphoryla...

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Detalles Bibliográficos
Autores principales:	Padzik, Artur, Deshpande, Prasannakumar, Hollos, Patrik, Franker, Mariella, Rannikko, Emmy H., Cai, Dawen, Prus, Piotr, Mågård, Mats, Westerlund, Nina, Verhey, Kristen J., James, Peter, Hoogenraad, Casper C., Coffey, Eleanor T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791394/ https://www.ncbi.nlm.nih.gov/pubmed/27013971 http://dx.doi.org/10.3389/fncel.2016.00057

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