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Osteoporotic Fracture Risk Assessment Using Bone Mineral Density in Korean: A Community-based Cohort Study

BACKGROUND: Fracture-risk assessment tool (FRAX) using just clinical risk factors of osteoporosis has been developed to estimate individual risk of osteoporotic fractures. We developed prediction model of fracture risk using bone mineral density (BMD) as well as clinical risk factors in Korean, and...

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Autores principales: Jang, Eun Jin, Lee, Young-Kyun, Choi, Hyung Jin, Ha, Yong-Chan, Jang, Sunmee, Shin, Chan Soo, Cho, Nam Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Bone and Mineral Research 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791436/
https://www.ncbi.nlm.nih.gov/pubmed/26981519
http://dx.doi.org/10.11005/jbm.2016.23.1.34
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author Jang, Eun Jin
Lee, Young-Kyun
Choi, Hyung Jin
Ha, Yong-Chan
Jang, Sunmee
Shin, Chan Soo
Cho, Nam Han
author_facet Jang, Eun Jin
Lee, Young-Kyun
Choi, Hyung Jin
Ha, Yong-Chan
Jang, Sunmee
Shin, Chan Soo
Cho, Nam Han
author_sort Jang, Eun Jin
collection PubMed
description BACKGROUND: Fracture-risk assessment tool (FRAX) using just clinical risk factors of osteoporosis has been developed to estimate individual risk of osteoporotic fractures. We developed prediction model of fracture risk using bone mineral density (BMD) as well as clinical risk factors in Korean, and assessed the validity of the final model. METHODS: To develop and validate an osteoporotic FRAX, a total of 768 Korean men and women aged 50 to 90 years were followed for 7 years in a community-based cohort study. BMD as well as clinical risk factors for osteoporotic fracture including age, sex, body mass index, history of fragility fracture, family history of fracture, smoking status, alcohol intake, use of oral glucocorticoid, rheumatoid arthritis, and other causes of secondary osteoporosis were assessed biannually. RESULTS: During the follow-up period, 86 osteoporotic fractures identified (36 in men and 50 in women). The developed prediction models showed high discriminatory power and had goodness of fit. CONCLUSIONS: The developed a Korean specific prediction model for osteoporotic fractures can be easily used as a screening tool to identify individual with high risk of osteoporotic fracture. Further studies for validation are required to confirm the clinical feasibility in general Korean population.
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spelling pubmed-47914362016-03-15 Osteoporotic Fracture Risk Assessment Using Bone Mineral Density in Korean: A Community-based Cohort Study Jang, Eun Jin Lee, Young-Kyun Choi, Hyung Jin Ha, Yong-Chan Jang, Sunmee Shin, Chan Soo Cho, Nam Han J Bone Metab Original Article BACKGROUND: Fracture-risk assessment tool (FRAX) using just clinical risk factors of osteoporosis has been developed to estimate individual risk of osteoporotic fractures. We developed prediction model of fracture risk using bone mineral density (BMD) as well as clinical risk factors in Korean, and assessed the validity of the final model. METHODS: To develop and validate an osteoporotic FRAX, a total of 768 Korean men and women aged 50 to 90 years were followed for 7 years in a community-based cohort study. BMD as well as clinical risk factors for osteoporotic fracture including age, sex, body mass index, history of fragility fracture, family history of fracture, smoking status, alcohol intake, use of oral glucocorticoid, rheumatoid arthritis, and other causes of secondary osteoporosis were assessed biannually. RESULTS: During the follow-up period, 86 osteoporotic fractures identified (36 in men and 50 in women). The developed prediction models showed high discriminatory power and had goodness of fit. CONCLUSIONS: The developed a Korean specific prediction model for osteoporotic fractures can be easily used as a screening tool to identify individual with high risk of osteoporotic fracture. Further studies for validation are required to confirm the clinical feasibility in general Korean population. The Korean Society for Bone and Mineral Research 2016-02 2016-02-29 /pmc/articles/PMC4791436/ /pubmed/26981519 http://dx.doi.org/10.11005/jbm.2016.23.1.34 Text en Copyright © 2016 The Korean Society for Bone and Mineral Research http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jang, Eun Jin
Lee, Young-Kyun
Choi, Hyung Jin
Ha, Yong-Chan
Jang, Sunmee
Shin, Chan Soo
Cho, Nam Han
Osteoporotic Fracture Risk Assessment Using Bone Mineral Density in Korean: A Community-based Cohort Study
title Osteoporotic Fracture Risk Assessment Using Bone Mineral Density in Korean: A Community-based Cohort Study
title_full Osteoporotic Fracture Risk Assessment Using Bone Mineral Density in Korean: A Community-based Cohort Study
title_fullStr Osteoporotic Fracture Risk Assessment Using Bone Mineral Density in Korean: A Community-based Cohort Study
title_full_unstemmed Osteoporotic Fracture Risk Assessment Using Bone Mineral Density in Korean: A Community-based Cohort Study
title_short Osteoporotic Fracture Risk Assessment Using Bone Mineral Density in Korean: A Community-based Cohort Study
title_sort osteoporotic fracture risk assessment using bone mineral density in korean: a community-based cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791436/
https://www.ncbi.nlm.nih.gov/pubmed/26981519
http://dx.doi.org/10.11005/jbm.2016.23.1.34
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