Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis

BACKGROUND: Despite the significant global loss of DNA hydroxymethylation marks in prostate cancer tissues, the locus-specific role of hydroxymethylation in prostate tumorigenesis is unknown. We characterized hydroxymethylation and methylation marks by performing whole-genome next-generation sequenc...

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Detalles Bibliográficos
Autores principales: Kamdar, Shivani N., Ho, Linh T., Kron, Ken J., Isserlin, Ruth, van der Kwast, Theodorus, Zlotta, Alexandre R., Fleshner, Neil E., Bader, Gary, Bapat, Bharati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791926/
https://www.ncbi.nlm.nih.gov/pubmed/26981160
http://dx.doi.org/10.1186/s13148-016-0195-4

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