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Engineered nanomaterials: toward effective safety management in research laboratories

BACKGROUND: It is still unknown which types of nanomaterials and associated doses represent an actual danger to humans and environment. Meanwhile, there is consensus on applying the precautionary principle to these novel materials until more information is available. To deal with the rapid evolution...

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Autores principales: Groso, Amela, Petri-Fink, Alke, Rothen-Rutishauser, Barbara, Hofmann, Heinrich, Meyer, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791936/
https://www.ncbi.nlm.nih.gov/pubmed/26979818
http://dx.doi.org/10.1186/s12951-016-0169-x
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author Groso, Amela
Petri-Fink, Alke
Rothen-Rutishauser, Barbara
Hofmann, Heinrich
Meyer, Thierry
author_facet Groso, Amela
Petri-Fink, Alke
Rothen-Rutishauser, Barbara
Hofmann, Heinrich
Meyer, Thierry
author_sort Groso, Amela
collection PubMed
description BACKGROUND: It is still unknown which types of nanomaterials and associated doses represent an actual danger to humans and environment. Meanwhile, there is consensus on applying the precautionary principle to these novel materials until more information is available. To deal with the rapid evolution of research, including the fast turnover of collaborators, a user-friendly and easy-to-apply risk assessment tool offering adequate preventive and protective measures has to be provided. RESULTS: Based on new information concerning the hazards of engineered nanomaterials, we improved a previously developed risk assessment tool by following a simple scheme to gain in efficiency. In the first step, using a logical decision tree, one of the three hazard levels, from H1 to H3, is assigned to the nanomaterial. Using a combination of decision trees and matrices, the second step links the hazard with the emission and exposure potential to assign one of the three nanorisk levels (Nano 3 highest risk; Nano 1 lowest risk) to the activity. These operations are repeated at each process step, leading to the laboratory classification. The third step provides detailed preventive and protective measures for the determined level of nanorisk. CONCLUSIONS: We developed an adapted simple and intuitive method for nanomaterial risk management in research laboratories. It allows classifying the nanoactivities into three levels, additionally proposing concrete preventive and protective measures and associated actions. This method is a valuable tool for all the participants in nanomaterial safety. The users experience an essential learning opportunity and increase their safety awareness. Laboratory managers have a reliable tool to obtain an overview of the operations involving nanomaterials in their laboratories; this is essential, as they are responsible for the employee safety, but are sometimes unaware of the works performed. Bringing this risk to a three-band scale (like other types of risks such as biological, radiation, chemical, etc.) facilitates the management for occupational health and safety specialists. Institutes and school managers can obtain the necessary information to implement an adequate safety management system. Having an easy-to-use tool enables a dialog between all these partners, whose semantic and priorities in terms of safety are often different. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12951-016-0169-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-47919362016-03-16 Engineered nanomaterials: toward effective safety management in research laboratories Groso, Amela Petri-Fink, Alke Rothen-Rutishauser, Barbara Hofmann, Heinrich Meyer, Thierry J Nanobiotechnology Research BACKGROUND: It is still unknown which types of nanomaterials and associated doses represent an actual danger to humans and environment. Meanwhile, there is consensus on applying the precautionary principle to these novel materials until more information is available. To deal with the rapid evolution of research, including the fast turnover of collaborators, a user-friendly and easy-to-apply risk assessment tool offering adequate preventive and protective measures has to be provided. RESULTS: Based on new information concerning the hazards of engineered nanomaterials, we improved a previously developed risk assessment tool by following a simple scheme to gain in efficiency. In the first step, using a logical decision tree, one of the three hazard levels, from H1 to H3, is assigned to the nanomaterial. Using a combination of decision trees and matrices, the second step links the hazard with the emission and exposure potential to assign one of the three nanorisk levels (Nano 3 highest risk; Nano 1 lowest risk) to the activity. These operations are repeated at each process step, leading to the laboratory classification. The third step provides detailed preventive and protective measures for the determined level of nanorisk. CONCLUSIONS: We developed an adapted simple and intuitive method for nanomaterial risk management in research laboratories. It allows classifying the nanoactivities into three levels, additionally proposing concrete preventive and protective measures and associated actions. This method is a valuable tool for all the participants in nanomaterial safety. The users experience an essential learning opportunity and increase their safety awareness. Laboratory managers have a reliable tool to obtain an overview of the operations involving nanomaterials in their laboratories; this is essential, as they are responsible for the employee safety, but are sometimes unaware of the works performed. Bringing this risk to a three-band scale (like other types of risks such as biological, radiation, chemical, etc.) facilitates the management for occupational health and safety specialists. Institutes and school managers can obtain the necessary information to implement an adequate safety management system. Having an easy-to-use tool enables a dialog between all these partners, whose semantic and priorities in terms of safety are often different. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12951-016-0169-x) contains supplementary material, which is available to authorized users. BioMed Central 2016-03-15 /pmc/articles/PMC4791936/ /pubmed/26979818 http://dx.doi.org/10.1186/s12951-016-0169-x Text en © Groso et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Groso, Amela
Petri-Fink, Alke
Rothen-Rutishauser, Barbara
Hofmann, Heinrich
Meyer, Thierry
Engineered nanomaterials: toward effective safety management in research laboratories
title Engineered nanomaterials: toward effective safety management in research laboratories
title_full Engineered nanomaterials: toward effective safety management in research laboratories
title_fullStr Engineered nanomaterials: toward effective safety management in research laboratories
title_full_unstemmed Engineered nanomaterials: toward effective safety management in research laboratories
title_short Engineered nanomaterials: toward effective safety management in research laboratories
title_sort engineered nanomaterials: toward effective safety management in research laboratories
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791936/
https://www.ncbi.nlm.nih.gov/pubmed/26979818
http://dx.doi.org/10.1186/s12951-016-0169-x
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