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The position of lysosomes within the cell determines their luminal pH

We examined the luminal pH of individual lysosomes using quantitative ratiometric fluorescence microscopy and report an unappreciated heterogeneity: peripheral lysosomes are less acidic than juxtanuclear ones despite their comparable buffering capacity. An increased passive (leak) permeability to pr...

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Detalles Bibliográficos
Autores principales:	Johnson, Danielle E., Ostrowski, Philip, Jaumouillé, Valentin, Grinstein, Sergio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792074/ https://www.ncbi.nlm.nih.gov/pubmed/26975849 http://dx.doi.org/10.1083/jcb.201507112

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